以HPMC K15M、HPMC K4M制备双氯芬酸钠亲水凝胶骨架片,采用肠溶欧巴代进行包衣,并研究了肠溶缓释片的体外释放度.缓释片处方为主药:HPMC K15M∶ HPMC K4M∶ MCC∶乳糖:硬脂酸镁=75∶50∶20∶ 115∶ 40∶3;包衣材料为12％的肠溶欧巴代水溶液,药片增重3％～4％;体外释放情况为2h∶37.2％,6h∶70.9％,12h:92.2％,对药物的释放情况进行拟合,符合一级方程.
We use HPMC K15M&HPMC K4M to make preparation of Diclofenac Sodium hydrophlic gel matrix sustained-release tablets,the enteric material is Opadry.And study the in vitro dissolution rate of enteric-coated sustained-release tablets.The formulation of sustained release tablets is Drug∶ HPMC K15M∶ HPMC K4M∶ MCC∶ lactose∶ =75∶ 50∶ 20∶115∶40∶ 3.The coating materials is 12％ enteric Opadry aqueous solution,tablet weight increase of 3 ％ to 4％;In vitro release of 2h:37.2％,6h:70.9％,12h:92.2％,fitting the release of the drug with the first-order equation.
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