Three dimensional(3D)printing technology was utilized to fabricate a new type of drug implant with complicated architectures,employing levofloxacin(LVFX)and rifampicine(RFP) as model drugs.The prepared drug implant prototype consists of a double-layer structure,of which the upper region is a reservoir system containing RFP and the lower region is a matrix one containing LVFX.The release test in vivo revealed that LVFX was released in the early stage;no RFP was de-tected until 8th day;both of them continuously released more than 6 weeks.Therefore,3D printing technology provides a precise and feasible method to fabricate a controlled-releasing drug implant with complicated architectures and this drug implant may present a new strategy for the prophylaxis and treatment of bone diseases such as combined bone infections and bone tuberculosis in the near future.
参考文献
| [1] | Mendel V;Simanowski HJ;Scholz HC;Heymann H .Therapy with gentamicin-PMMA beads, gentamicin-collagen sponge, and cefazolin for experimental osteomyelitis due to Staphylococcus aureus in rats.[J].Archives of orthopaedic and trauma surgery,2005(6):363-368. |
| [2] | Joosten U;Joist A;Gosheger G;Liljenqvist U;Brandt B;von Eiff C .Effectiveness of hydroxyapatite-vancomycin bone cement in the treatment of Staphylococcus aureus induced chronic osteomyelitis.[J].Biomaterials,2005(25):5251-5258. |
| [3] | Hanssen AD .Local antibiotic delivery vehicles in the treatment of musculoskeletal infection.[J].Clinical Orthopaedics and Related Research,2005(437):91-96. |
| [4] | Chu TM;Orton DG;Hollister SJ;Feinberg SE;Halloran JW .Mechanical and in vivo performance of hydroxyapatite implants with controlled architectures.[J].Biomaterials,2002(5):1283-1293. |
| [5] | ZHENG Qi-xin,GUO Xiao-dong,DU Jing-yuan,WU Yong-chao,QUAN Da-ping,YAN Yu-hua,LI Shi-pu.Biodegradation of Absorbable Hydroxyapatite/Poly-DL-lactide Composites in Different Environment[J].武汉理工大学学报(材料科学版)英,2002(03):24-29. |
| [6] | Castro C.;Sanchez E.;Delgado A.;Soriana I.;Nunez P.;Baro M.;Perera A.;Evora C. .Ciprofloxacin implants for bone infection. In vitro-in vivo characterization[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2003(3):341-354. |
| [7] | Sherwood J;Riley S;Palazzolo R;Brown S;Monkhouse D;Coates M;Griffith L;Landeen L;Ratcliffe A .A three-dimensional osteochondral composite scaffold for articular cartilage repair.[J].Biomaterials,2002(24):4739-0. |
| [8] | Huang W;Zheng Q;Sun W;Xu H;Yang X .Levofloxacin implants with predefined microstructure fabricated by three-dimensional printing technique.[J].International Journal of Pharmaceutics,2007(1/2):33-38. |
| [9] | Leong KF;Cheah CM;Chua CK .Solid freeform fabrication of three-dimensional scaffolds for engineering replacement tissues and organs.[J].Biomaterials,2003(13):2363-2378. |
| [10] | Sachlos E.;Reis N.;Ainsley C.;Derby B.;Czernuszka JT. .Novel collagen scaffolds with predefined internal morphology made by solid freeform fabrication[J].Biomaterials,2003(8):1487-1497. |
| [11] | Ambrose CG;Gogola GR;Clyburn TA;Raymond AK;Peng AS;Mikos AG .Antibiotic microspheres: preliminary testing for potential treatment of osteomyelitis.[J].Clinical Orthopaedics and Related Research,2003(415):279-285. |
| [12] | Kanellakopoulou K;Giamarellos Bourboulis-EJ .Carrier systems for the local delivery of antibiotics in bone infections.[J].Drugs: International Journal of Current Therapeutics and Applied Pharmacology Reviews, Featuring Evaluations on New Drugs, Review Articles on Drugs and Drug Therapy, and Drug Literature Abstracts,2000(6):1223-1232. |
| [13] | Wang G;Liu SJ;Ueng SW;Chan EC .The release of cefazolin and gentamicin from biodegradable PLA/PGA beads.[J].International Journal of Pharmaceutics,2004(1/2):203-212. |
| [14] | Ruszczak Z;Friess W .Collagen as a carrier for on-site delivery of antibacterial drugs.[J].Advanced drug delivery reviews,2003(12):1679-1698. |
| [15] | Julian R.Jones;Samit Ahir;Larry L.Hench .Large-Scale Production of 3D Bioactive Glass Macroporous Scaffolds for Tissue Engineering[J].Journal of Sol-Gel Science and Technology,2004(3):179-188. |
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