A novel pH-sensitive complex was prepared by using oxidized konjac glucomannan and 4-aminosalicylic acid (4-ASA) through glutaraldehyde as a cross-linking agent. The product was characterized by FTIR and ~(13)C NMR spectra, and the thermogravimetric analysis was also studied. The drug release studies in vitro showed that the amount of 4-ASA released from the complex was about 4%, 56% and 17% after 12 h at pH 1.2, 6.8 and 7.4, respectively. The data demonstrate that the rate of the drug release of the complex can be more effectively controlled by pH value. The results showed that the novel pH-sensitive complex could be potentially useful for colon-targeting drug delivery system.
参考文献
| [1] | Sinha VR;Kumria R .Polysaccharides in colon-specific drug delivery.[J].International Journal of Pharmaceutics,2001(1/2):19-38. |
| [2] | Nunthanid J;Huanbutta K;Luangtana-Anan M;Sriamornsak P;Limmatvapirat S;Puttipipatkhachorn S .Development of time-, pH-, and enzyme-controlled colonic drug delivery using spray-dried chitosan acetate and hydroxypropyl methylcellulose.[J].European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fuer Pharmazeutische Verfahrenstechnik e.V,2008(2):253-259. |
| [3] | Salmaso S;Semenzato A;Bersani S;Matricardi P;Rossi F;Caliceti P .Cyclodextrin/PEG based hydrogels for multi-drug delivery.[J].International Journal of Pharmaceutics,2007(1/2):42-50. |
| [4] | Yihong Huang;Huiqun Yu;Chaobo Xiao .pH-sensitive cationic guar gum/poly(acrylic acid)polyelectrolyte hydrogels:Swelling and in vitro drug release[J].Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides,2007(4):774-783. |
| [5] | Jantarat C;Tangthong N;Songkro S;Martin GP;Suedee R .S-propranolol imprinted polymer nanoparticle-on-microsphere composite porous cellulose membrane for the enantioselectively controlled delivery of racemic propranolol.[J].International Journal of Pharmaceutics,2008(1/2):212-225. |
| [6] | Li-Gui Chen;Zhi-Lan Liu;Ren-Xi Zhuo .Synthesis and properties of degradable hydrogels of konjac glucomannan grafted acrylic acid for colon-specific drug delivery[J].Polymer: The International Journal for the Science and Technology of Polymers,2005(16):6274-6281. |
| [7] | Jian Du;Jing Dai;Jun-Long Liu;Theresa Dankovich .Novel pH-sensitive polyelectrolyte carboxymethyl Konjac glucomannan-chitosan beads as drug carriers[J].Reactive & functional polymers,2006(10):1055-1061. |
| [8] | Zhang H.;Nishinari K.;Williams MAK.;Foster TJ.;Norton IT.;Yoshimura M. .Gelation behaviour of konjac glucomannan with different molecular weights[J].Biopolymers: Original Research on Biomolecules and Biomolecular Assemblies,2001(1):38-50. |
| [9] | Lee KY.;Mooney DJ.;Bouhadir KH. .Degradation behavior of covalently cross-linked poly(aldehyde guluronate) hydrogels[J].Macromolecules,2000(1):97-101. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%