A multiwall carbon nanotube modified electrode prepared by incorporating multiwall carbon nanotubes in the electrode of a sensor and naphthol green as a homogeneous mediator was used as a voltammetric sensor for the determination of N-actylcysteine (N-AC) in the presence of tryptophan (Trp). The voltammograms of differential pulse voltammetry of N-AC in a mixture with Trp were separated from each other by a potential difference of 200 mV, which allowed the determination of both N-AC and Trp simultaneously. Under the optimum conditions, the electrocatalytic currents increased linearly with N-AC concentration in the range of 0.25-400 μmol/L (two linear segments with different slopes). The detection limit for N-AC was 0.08 μmol/L. The kinetic parameters of the system were determined using electrochemical methods. The method was applied for the determination of N-AC in drug and urine samples.
参考文献
| [1] | Keyvanfard M;Shakeri R;Karimi-Maleh H;Alizad K .[J].MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS,2013,33:811. |
| [2] | Ensafi A A;Bahrami H;Rezaei B;Karimi-Maleh H .[J].MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS,2013,33:831. |
| [3] | Salmanpour, S.;Tavana, T.;Pahlavan, A.;Khalilzadeh, M.A.;Ensafi, A.A.;Karimi-Maleh, H.;Beitollahi, H.;Kowsari, E.;Zareyee, D. .Voltammetric determination of norepinephrine in the presence of acetaminophen using a novel ionic liquid/multiwall carbon nanotubes paste electrode[J].Materials science & engineering, C. Biomimetic and supramolecular systems,2012(7):1912-1918. |
| [4] | Bijad, M.;Karimi-Maleh, H.;Khalilzadeh, M. A. .Application of ZnO/CNTs nanocomposite ionic liquid paste electrode as a sensitive voltammetric sensor for determination of ascorbic acid in food samples.[J].Food analytical methods,2013(6):1639-1647. |
| [5] | Tavana, T.;Khalilzadeh, M.A.;Karimi-Maleh, H.;Ensafi, A.A.;Beitollahi, H.;Zareyee, D..Sensitive voltammetric determination of epinephrine in the presence of acetaminophen at a novel ionic liquid modified carbon nanotubes paste electrode[J].Journal of Molecular Liquids,2012:69-74. |
| [6] | Ensafi, A.A.;Karimi-Maleh, H.;Mallakpour, S.;Rezaei, B. .Highly sensitive voltammetric sensor based on catechol-derivative-multiwall carbon nanotubes for the catalytic determination of captopril in patient human urine samples[J].Colloids and Surfaces, B. Biointerfaces,2011(2):480-488. |
| [7] | Ensafi A A;Lotfi M;Karimi-Maleh H .[J].催化学报,2012,33:487. |
| [8] | Beitollah, H.;Goodarzian, M.;Khalilzadeh, M.A.;Karimi-Maleh, H.;Hassanzadeh, M.;Tajbakhsh, M..Electrochemical behaviors and determination of carbidopa on carbon nanotubes ionic liquid paste electrode[J].Journal of Molecular Liquids,2012:137-143. |
| [9] | Mokhtari, A.;Karimi-Maleh, H.;Ensafi, A.A.;Beitollahi, H. .Application of modified multiwall carbon nanotubes paste electrode for simultaneous voltammetric determination of morphine and diclofenac in biological and pharmaceutical samples[J].Sensors and Actuators, B. Chemical,2012(1):96-105. |
| [10] | Ensafi A A;Karimi-Maleh H;Mallakpour S .[J].Col oids Surf B,2013,104:186. |
| [11] | Boman G;Backer U;Larsson S;Melander B Wahlinder L .[J].European Journal of Respiratory Diseases,1983,64:405. |
| [12] | Multicenter Study Group .[J].European Journal of Respiratory Diseases,1980,61(Suppl):93. |
| [13] | Prescott L F;Illingworth R N;Critchley J A J H;Stewart M J Adam R D Proudfoot A T .[J].BRITISH MEDICAL JOURNAL,1979,2:1097. |
| [14] | Saernstrand B;Tunek A;Sjoedin K;Hallberg A .[J].Chemico-Biological Interactions,1995,94:157. |
| [15] | Moldeus P;Cotgreave I A;Berggren M .[J].RESPIRATION,1986,50(Suppl 1):31. |
| [16] | Holodiness M R .[J].ClinPharmacokinet,1991,20:123. |
| [17] | Cuzzocrea,S;Mazzon,E;Costantino,G;Serraino,I;De,Sarro-A;Caputi,AP .Effects of n-acetylcysteine in a rat model of ischemia and reperfusion injury.[J].Cardiovascular Research,2000(3):537-548. |
| [18] | Concha-Herrera V;Torres-Lapasio J R;Garcia-Alvarez-Coque M C .[J].Journal of Liquid Chromatography and Related Technologies,2004,27:1593. |
| [19] | Tsikas D;Sandmann J;Ikic M;Fauler J Stichtenoth D O Frolich J C .[J].Journal of Chromatography B,1998,708:55. |
| [20] | Tsai FY.;Chien CS.;Chen CJ. .DETERMINATION OF THE CYSTEINE DERIVATIVES N-ACETYLCYSTEINE, S-CARBOXYMETHYLCYSTEINE AND METHYLCYSTEINE IN PHARMACEUTICALS BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY[J].Journal of chromatography, A: Including electrophoresis and other separation methods,1995(1/2):309-315. |
| [21] | Garcia Alvarez-Coque M C;Medina Hernandez M J;Villanueva Camanas R M;Mongay Fernandez C .[J].ANALYST,1989,114:975. |
| [22] | Raggi M A;Cavrini V;Di Pietra A M .[J].Journal of Pharmaceutical Sciences,1982,71:1384. |
| [23] | Suarez WT;Vieira HJ;Fatibello Filho O .Generation and destruction of unstable reagent in flow injection system: determination of acetylcysteine in pharmaceutical formulations using bromine as reagent.[J].Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis,2005(4):771-775. |
| [24] | Fornazari A;Suarez W T;Vieira H J;Fatibello-Filho O .[J].ACTA CHIMICA SLOVENICA,2005,52:164. |
| [25] | Al-Ghannam S M;El-Brashy A M;Al-Farhan B M .[J].FARMACO,2002,57:625. |
| [26] | Suarez W T;Madi A A;Vicentini F C;Fatibello-Filho O .[J].Analytical Letters,2007,40:3417. |
| [27] | Raoof, J.B.;Ojani, R.;Amiri-Aref, M.;Chekin, F. .Catechol as an electrochemical indicator for voltammetric determination of N-Acetyl-L-cysteine in aqueous media at the surface of carbon paste electrode[J].Journal of Applied Electrochemistry,2010(7):1357-1363. |
| [28] | Ensafi, A.A.;Karimi-Maleh, H.;Mallakpour, S.;Hatami, M. .Simultaneous determination of N-acetylcysteine and acetaminophen by voltammetric method using N-(3,4-dihydroxyphenethyl)-3,5-dinitrobenzamide modified multiwall carbon nanotubes paste electrode[J].Sensors and Actuators, B. Chemical,2011(2):464-472. |
| [29] | Beitollahi, H.;Raoof, J.-B.;Hosseinzadeh, R. .Fabrication of a nanostructure-based electrochemical sensor for simultaneous determination of N-acetylcysteine and acetaminophen[J].Talanta: The International Journal of Pure and Applied Analytical Chemistry,2011(4):2128-2134. |
| [30] | Fernstrom M H;Fernstrom J D .[J].Life Sciences,1995,57:97. |
| [31] | Kochen W;Steinhart H.L-Tryptophan-Current Prospects in Medi-cine and Drug Safety[M].de-Gruyter,Berlin,1994 |
| [32] | Fiorucci A R;Cavalheiro E T G .[J].Journal of Pharmaceutical and Biomedical Analysis,2002,28:909. |
| [33] | Kutlán D;Molnár-Perl I .[J].Journal of Chromatography A,2003,987:311. |
| [34] | You J M;Shan Y C;Zhen L;Zhang L Zhang Y K .[J].Analytical Biochemistry,2003,313:17. |
| [35] | Dale Y;Mackey V;Mushi R;Nyanda A Maleque M Ike J .[J].J Chroma-togr B,2003,788:1. |
| [36] | Wang J;Mannino S;Camera C;Chatrathi MP;Scampicchio M;Zima J .Microchip capillary electrophoresis with amperometric detection for rapid separation and detection of seleno amino acids[J].Journal of chromatography, A: Including electrophoresis and other separation methods,2005(1/2):177-182. |
| [37] | Lee, CJ;Yang, J .alpha-Cyclodextrin-modified infrared chemical sensor for selective determination of tyrosine in biological fluids[J].Analytical Biochemistry,2006(1):124-131. |
| [38] | Simionato A V C;Moraes E P;Carrilho E;Tavares M F M Kenndler E .[J].ELECTROPHORESIS,2008,29:2051. |
| [39] | Underberg WJM.;Waterval JCM. .Derivatization trends in capillary electrophoresis: An update [Review][J].Electrophoresis: The Official Journal of the International Electrophoresis Society,2002(22/23):3922-3933. |
| [40] | Sikorska E;Gliszczynska-Swiglo A;Insinska-Rak M;Khmelinskii I De Keukeleire D Sikorski M .[J].Analytica Chimica Acta,2008,613:207. |
| [41] | Alonso M C S;Zamora L L;Calatayud J M .[J].TALANTA,2003,60:369. |
| [42] | Bertini J;Mannucci C;Noferini R;Perico A Rovero P .[J].Journal of Pharmaceutical Sciences,1993,82:179. |
| [43] | Raoof JB;Ojani R;Karimi-Maleh H .Carbon paste electrode incorporating 1-[4-(ferrocenyl ethynyl) phenyl]-1-ethanone for electrocatalytic and voltammetric determination of tryptophan[J].Electroanalysis,2008(11):1259-1262. |
| [44] | Guo Y J;Guo S J;Fang Y X;Dong S J .[J].Electrochimica Acta,2010,55:3927. |
| [45] | Keyvanfard M;Karimi-Maleh H;Alizad K .[J].催化学报,2013,34:1883. |
| [46] | Ensafi A A;Bahrami H;Karimi-Maleh H;Mallakpour S .[J].催化学报,2012,33:1919. |
| [47] | Habibi B;Abazari M;Pournaghi-Azar M H .[J].催化学报,2012,33:1783. |
| [48] | Raoof J B;Ojani R;Baghayeri M .[J].催化学报,2011,32 |
| [49] | Karimi-Maleh H;Biparva P;Hatami M.[J].BIOSENSORS & BIOELECTRONICS,2013 |
| [50] | Beitollahi H;Mohadesi A;Ghorbani F;Karimi-Maleh H Baghayeri M Hosseinzadeh R .[J].催化学报,2013,34:1333. |
| [51] | Ensafi A A;Heydari-Bafrooei E;Rezaei B .[J].催化学报,2013,34:1768. |
| [52] | Elyasi M;Khalilzadeh M A;Karimi-Maleh H .[J].Food Chemistry,2013,141 |
| [53] | Sanati A L;Karimi-Maleh H;Badiei A;Biparva P Ensafi A A .[J].MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS,2014,35:379. |
| [54] | Karim-Nezhad G;Pashazadeh S;Pashazadeh A .[J].催化学报,2012,33:1809. |
| [55] | Moradi R;Sebt S A;Karimi-Maleh H;Sadeghi R Karimi F Bahari A Arabi H .[J].Physical Chemistry Chemical Physics,2013,15:5888. |
| [56] | Beitollahi H;Karimi-Maleh H;Khabazzadeh H .[J].Analytical Chemistry,2008,80:9848. |
| [57] | Ensafi, AA;Karimi-Maleh, H .Modified multiwall carbon nanotubes paste electrode as a sensor for simultaneous determination of 6-thioguanine and folic acid using ferrocenedicarboxylic acid as a mediator[J].Journal of Electroanalytical Chemistry: An International Journal Devoted to All Aspects of Electrode Kinetics, Interfacial Structure, Properties of Electrolytes, Colloid and Biological Electrochemistry,2010(1/2):75-83. |
| [58] | Roodbari Shahmiri M;Bahari A;Karimi-Maleh H;Hosseinzadeh R Mirnia N .[J].Sensors and Actuators B-Chemical,2013,177:70. |
| [59] | Galus Z.Fundumentals of Electrochemical Analysis[M].Ellis Horwood,New York,1976 |
| [60] | Gao ZN;Zhang J;Liu WY .Electrocatalytic: oxidation of N-acetyl-L-cysteine by acetylferrocene at glassy carbon electrode[J].Journal of Electroanalytical Chemistry: An International Journal Devoted to All Aspects of Electrode Kinetics, Interfacial Structure, Properties of Electrolytes, Colloid and Biological Electrochemistry,2005(1):9-16. |
| [61] | Raoof, JB;Ojani, R;Chekin, F;Jahanshahi, M;Rashid-Nadimi, S .Fabrication of Nanocomposite Containing Naphthoquinone and Nanogold Supported on Poly(2,6-pyridinedicarboxylic acid) Film for Voltammetric Determination of N-Acetyl-L-Cysteine[J].Electroanalysis,2009(24):2674-2679. |
| [62] | Shahrokhian S;Kamalzadeh Z;Bezzaatpour A;Boghaei DM .Differential pulse voltammetric determination of N-acetylcysteine by the electrocatalytic oxidation at the surface of carbon nanotube-paste electrode modified with cobalt salophen complexes[J].Sensors and Actuators, B. Chemical,2008(2):599-606. |
| [63] | Pournaghi-Azar MH;Ahour F .Palladized aluminum electrode covered by Prussian blue film as an effective transducer for electrocatalytic oxidation and hydrodynamic amperometry of N-acetyl-cysteine and glutathione[J].Journal of Electroanalytical Chemistry: An International Journal Devoted to All Aspects of Electrode Kinetics, Interfacial Structure, Properties of Electrolytes, Colloid and Biological Electrochemistry,2008(1):22-28. |
| [64] | Karimi-Maleh H;Keyvanfard M;Alizad K;Fouladgar M Beitollahi H Mokhtari A Gholami-Orimi F .[J].International Journal of Electrochemical Science,2011,6:6141. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%