通过η3-苄基钯中间体零价钯催化的吲哚苄基化反应

催化学报 , 2015, (1): 15-18. doi: 10.1016/S1872-2067(14)60191-1

通过η3-苄基钯中间体零价钯催化的吲哚苄基化反应

1.华东理工大学结构可控先进功能材料及其制备教育部重点实验室和精细化工研究所，上海200237; 中国科学院上海有机化学研究所金属有机国家重点实验室，上海200032

2.中国科学院上海有机化学研究所金属有机国家重点实验室,上海,200032

3.华东理工大学结构可控先进功能材料及其制备教育部重点实验室和精细化工研究所,上海,200237

4.华东理工大学结构可控先进功能材料及其制备教育部重点实验室和精细化工研究所，上海200237; 中国科学院上海有机化学研究所金属有机国家重点实验室，上海200032

基金项目: the National Basic Research Program of China(973 Program,2010CB833300) 国家自然科学基金(21025209,21121062,21272253,21332009) the National Natural Science Founda-tion of China (21025209,21121062,21272253,21332009).基金来源:国家重点基础研究发展计划(973计划,2010CB833300)

关键词：苄基化 , 吲哚 , 三芳基甲烷 , η3-苄基钯中间体

Pd(0)-catalyzed benzylation of indole throughη3-benzyl palladium intermediate

Keywords： Benzylation , Indole , Triarylmethane , η3-Benzyl palladium intermediate

本文报道了零价钯催化的吲哚苄基化反应，获得了优秀的区域选择性。使用Pd(PPh3)4作为催化剂，在温和反应条件下，以90%–99%的收率获得含有各类取代吲哚片段的三芳基甲烷化合物。

An efficient method has been developed for the Pd(0)‐catalyzed benzylation of indoles, which oc‐curred with exclusive regioselectivity. When this reaction was performed in the presence of Pd(PPh3)4, it provided access to a broad range of substituted indoles bearing diarylmethanes at their 3‐position in 90%–99%yields under mild conditions.

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