三价铑催化硝酮与炔的碳氢活化偶联合成二氢吲哚

催化学报 , 2015, (7): 925-932. doi: 10.1016/S1872-2067(15)60866-X

三价铑催化硝酮与炔的碳氢活化偶联合成二氢吲哚

孔令恒 ^1, , 谢芳 ^2, , 于松杰 ^3, , 戚自松 ^4, , 李兴伟 ^5,

1.中国科学院大连化学物理研究所,辽宁大连,116023

2.中国科学院大连化学物理研究所,辽宁大连,116023

3.中国科学院大连化学物理研究所,辽宁大连,116023

4.中国科学院大连化学物理研究所,辽宁大连,116023

5.中国科学院大连化学物理研究所,辽宁大连,116023

基金项目: 国家自然科学基金(21272231,21472186,21372266) the Dalian Institute of Chemical Physics, Chinese Academy of Sciences, and the National Natural Science Foundation of China (21272231,21472186,21372266).基金来源:中国科学院大连化学物理研究所

关键词：三价铑 , 碳氢活化 , 氧转移 , 氮芳基硝酮

Rh(III)-catalyzed coupling of nitrones with alkynes for the synthesis of indolines

Keywords： Rhodium(III) , Carbon-hydrogen activation , Oxygen-atom transfer , Nitrogen-aryl nitrones

三价铑在氧化还原中性条件下催化硝酮与炔发生偶联，经过氮芳环的碳氢键活化和氧转移可以高化学选择性、中等到良好非对映选择性的得到三取代二氢吲哚。

Rh-catalyzed redox-neutral coupling betweenN-aryl nitrones and alkynes has been achieved under relatively mild conditions. The reaction proceeded via C–H activation at theN-aryl ring with subse-quent O-atom transfer, affording trisubstituted indolines in good chemoselectivity and moderate to good diasteroselectivity.

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