报道了水介质中金催化肌酸酐与不同靛红之间的醛醇缩合反应.该法无需繁杂的溶剂萃取和柱色谱技术,只需简单的过滤即可将产物分离出来,因而操作简单.通过较宽范围的靛红衍生物的反应,均可高产率并完全地制取相应的顺式醛醇缩合产物,因此该法表现出较高的通用性.还将该合成策略进一步拓展至靛红,肌酸酐和丙二腈的串联反应,可高产率、完全的制取反式多组分产物.采用分光光度法测定了合成产物的抗氧化性能,结果表明,与标准物相比,含有卤素原子的三个化合物(2c,2d和2e)表现出最高的活性.
The aldolization of various isatins with creatinine under gold catalysis in water has been developed. The reaction is operationally simple as the products can be isolated by simple filtration without requiring tedious solvent extraction and column chromatographic techniques. The generality of this methodology is showcased through the reactions of a wide range of isatin derivatives with creati-nine to afford the respective aldol products in excellent yields with complete syn-selectivity. The scope of this chemistry is further extended to a tandem reaction involving isatins, creatinine and malononitrile to afford multicomponent products in excellent yields with complete anti-selectivity. The antioxidant potency of the synthesized compound was assessed by a spectrophotometric method, which revealed that three compounds containing halogen atoms (2c, 2d and 2e) were the most active compared with the standard.
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