以活性炭为碳源,采用化学氧化结合ZnO包覆的方法制备新结构碳量子点,其稳定性好,荧光量子产率高。结果表明,甲硝唑对鲁米诺-高锰酸钾体系具有增敏作用,同时能有效猝灭碳量子点的荧光,以此建立化学发光法检测甲硝唑片含量。在最佳条件下,化学发光强度与甲硝唑的浓度呈良好的线性,其线性为7.5×10-4~2.5×10-8g/mL,线性相关系数r=0.9996,检测限CL=1.08×10-10g/mL。
ZnO-doped carbon quantum dots ( CQDs ) were prepared by the chemical oxidation of activated carbon followed by zinc acetate impregnation and precipitation. The ZnO-doped CQDs had a stable fluorescence and a high fluorescence quantum yield. The fluorescence of the ZnO-doped CQDs can be quenched by reduction with metronidazole, allowing a flow-injection chemilumi-nescence method to be used to determine the metronidazole content in tablets. Under optimum conditions, there was a good linear relation between the concentration of metronidazole and the intensity of chemiluminiscence. The linear concentration range examined was 7. 5×10-4-2. 5×10-8 g/mL with r = 0. 999 6 and a detection limit of 1. 08×10-10 g/mL.
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