文章综述了重离子束在物理学、生物学、临床治疗等方面的优势，以及在放射生物学方面的基础实验研究内容。分析总结了国内外重离子束辐照治疗肿瘤的临床研究结果。其中，日本已接受治疗了约6000名不同类型的肿瘤患者，并取得较高的局部控制率和生存率；德国在头颈部肿瘤临床治疗方面取得了巨大的成功；在兰州重离子研究装置(HIRFL)肿瘤治疗终端上，中国科学院近代物理研究所联合甘肃省肿瘤医院及兰州军区总医院对肿瘤患者的重离子治疗已进入临床试验阶段。甘肃省肿瘤医院治疗结果显示：43例患者通过影像学检查评价疗效，客观有效率(CR+PR)为71.4%，主要急性放射损伤为1-2级皮肤反应(红斑形成和脱皮)，发生率为61.9%，治疗1个月后随访结果显示重离子束(12C6+)对深部肿瘤具有较好的局部控制作用，且无严重不良反应发生。
10.11804/NuclPhysRev.30.02.166
参考文献
| [1] | GUO Xiaoying, LI Yingdong. Medical Information,2011,24(17):5963.(in Chinese)(郭晓?,李应东.临床医学,2011,24(17):5963.) |
| [2] | ZHONG Nanbao. Journal of Fuzhou General Hospital,2006,13(2):116.(in Chinese)(钟南保.福州总医院学报,2006,13(2):116.) |
| [3] | DING Xiaofan, CHEN Longhua. Chin J Radiol Med Prot,2006,26(5):536.(in Chinese)(丁小凡,陈龙华.中华放射医学与防护杂志,2006,26(5):536.) |
| [4] | XIAO Guoqing, ZHANG Hong, LI Qiang, et al. Nuclear Physics Review,2007,24(2):85.(in Chinese)(肖国青,张红,李强,等.原子核物理评论,2007,24(2):85.) |
| [5] | DEBUS J, HABERER T, SCHULZ-ERTNER D, et al. Len Ther Oncol,2000,176(5):211. |
| [6] | KAWACHI K. J Jpn Soc Ther Radiol Oncol,1989;(1):19. |
| [7] | KAMADA T. Int J Clin Oncol,2012,1(17):85. |
| [8] | LUO Guanghui, LI Wenjian, SU Xinggui. Guangdong Medical Journal,2007,28(1):159.(in Chinese)(罗光辉,李文建,苏兴桂.广东医学,2007,28(1):159.) |
| [9] | ELEANOR A B, AMY K. Radiation Research,1998,150:126. |
| [10] | ZHANG Xiaowen, WANG Xiaohu. Gansu Medical Journal,2011,30(2):65.(in Chinese)(张晓文,王小虎.甘肃医药,2011,30(2):65.) |
| [11] | YANG Lina, ZHANG Hong, DI Cuixia, et al. Nuclear Physics Re-view,2012,29(2):196.(in Chinese)(杨立娜,张红,狄翠霞,等.原子核物理评论,2012,29(2):196.) |
| [12] | GEORGAKILAS A. World Journal of Biological Chemistry,2011,2(7):173. |
| [13] | PEDDIP P, FRANCISCO D C, CECIL A M, et al. Cancer Letter,2008,269(1):174. |
| [14] | ASAITHAMBY A, HU B, CHEN D J. Proc Natl Acad Sci USA,2011,108(20):8293. |
| [15] | ASAITHAMBY A, CHEN D J. Mutat Res,2011,711(1/2):87. |
| [16] | XU Huihui, SUI Li, LIU Xiaodan, et al. Nuclear Physics Review,2010,27(4):469.(in Chinese)(徐辉辉,隋丽,刘晓丹,等.原子核物理评论,2010,27(4):469.) |
| [17] | ROIG A I, HIGHT S K, MINNA J D, et al. Int J Radiat Biol,2010,86(3):194. |
| [18] | BEVELACQUA J J, BEVELACQUA R. Radiation Protection Man-agement,2005,22(6):4. |
| [19] | LI Shanru, WANG Dongping, CHEN Yongfu. Hereditas,1998,20(1):38.(in Chinese)(李善如,王冬平,陈永福.遗传,1998,20(1):38.) |
| [20] | LI Wenjian, ZHANG Xiaowen. Nuclear Science and Techniques,2000,11(1):22 |
| [21] | WANG Jingfei, JIANG Yongping, LIANG Jianping, et al. Progress in Veterinary Medicine,2002,23(5):55(in Chinese)(王靖飞,姜永萍,梁剑平,等.动物医学进展,2002,23(5):55.) |
| [22] | DING Xiaofan, LI Wenjian, LI Dexing, et al. Chin J Radiol Med Prot,2005,25(1):45.(in Chinese)(丁小凡,李文建,李德杏,等.中华放射医学与防护杂志,2005,25(1):45.) |
| [23] | ZHENG Zhiming, WANG Ping, WANG Hongyan, et al. Interna-tional Journal of Radiation Oncology Biology Physics,2013,85(2):466. |
| [24] | ZHANG Luwei, LIU Yang, ZHANG Hong, et al. IMP&HIRFL Annual Report,2010:180. |
| [25] | HOU Weiwei, LIU Bin, ZHANG Gexiang, et al. Modern Preven-tive Medicine,2008,35(16):3060.(in Chinese)(侯玮玮,刘斌,张格祥,等.现代预防医学,2008,35(16):3060.) |
| [26] | DUAN Xin, ZHANG Hong, QIU Rong, et al. Nuclear Physics Re-view,2007,24(1):55.(in Chinese)(段昕,张红,邱嵘,等.原子核物理评论,2007,24(1):55.) |
| [27] | YANG Yingjie, GAO Gang, SU Xu, et al. Chin J Radiol Med Prot,2006,26(1):58.(in Chinese)(杨英杰,高刚,苏旭,等.中华放射医学与防护杂志,2006,26(1):58.) |
| [28] | MIZOE J E, HASEGAWA A, JINGU K, et al. Radiotherapy and Oncology,2012,1(103):32. |
| [29] | SUGANE T, BABA M, IMAI R. Lung Cancer.2009,1(64):45. |
| [30] | EMMANOUIL F, GERHARD K, HANXIANG A, et al. Biochimi-ca et Biophysica Acta,2009,2(1796):216. |
| [31] | SCHULZ-ERTNER D, NIKOGHOSYAN A, THILMANN C, et a1. Int J Radiat Oncol Biol Phys,2004,58(2):63l. |
| [32] | JAKEL O, KRAMER M, KARGER C P, et al. Phys Med Biol,2001,1(46):1101. |
| [33] | JAKEL O, KRAMER M, SCHULZ Ertner D, et al. Radiother On-col,2004,71(Suppl.2):S86. |
| [34] | CHEN Xuezhong, WANG Xiaohu. Gansu Medical Journal,2008,27(1):1.(in Chinese)(陈学忠,王小虎.甘肃医药,2008,27(1):1.) |
| [35] | WEI Zengquan, WEI Baowen. Physics,2001,30(8):485.(in Chi-nese)(卫增泉,魏宝文.物理,2001,30(8):485.) |
| [36] | 中国科学院院重离子辐射生物医学重点实验室建成斑马鱼研究平台[EB/OL].[2012-06-29]. http://www.imp.cas.cn/xwzx/kyjz/201011/t201011183023115.html. |
| [37] | ZHANG Hong, LI Sha, LI Qiang, et al. IMP & HIRFL Annual Report,2006:83. |
| [38] | LI Sha, ZHANG Hong, WEI Shihua, et al. Chin J Radiat Oncol,2008,17(6):463.(in Chinese)(李莎,张红,魏世华,等.中华放射肿瘤学杂志,2008,17(6):463.) |
| [39] | ZHANG Qiuning, WANG Xiaohu, ZHANG Hong, et al. Journal of Radiation Research and Radiation Processing,2010,28(5):316.(in Chinese)(张秋宁,王小虎,张红,等.辐射研究与辐射工艺学报,2010,28(5):316.) |
| [40] | CAI Hongyi, WANG Xiaohu, GAO Liying, et al. Chinese Journal of Cancer Prevention and Treatment,2010(14):1041.(in Chinese)(蔡宏懿,王小虎,高力英,等.中华肿瘤防治杂志,2010(14):1041.) |
| [41] | ZHANG Hong, LI Sha, WANG Xiaohu, et al. IMP&HIRFL An-nual Report,2007:103. |
| [42] | CAO Minli, LI Sha, ZHAO Hongbin, et al. Medical Journal of Na-tional Defending Forces in Northwest China,2010,31(4):250.(in Chinese)(曹敏丽,李莎,赵红斌,等.西北国防医学杂志,2010,31(4):250.) |
| [43] | WANG Xiaohu, ZHANG Hong, GAO Liying, et al. Chin J Radiat Oncol,2007,16(6):478.(in Chinese)(王小虎,张红,高力英,等.中华放射肿瘤学杂志,2007,16(6):478.) |
| [44] | CAO Minli, LI Sha, L ¨U Jianhong, et al. Med J NDFNC,2009,30(5):337.(in Chinese)(曹敏丽,李莎,吕建红,等.西北国防医学杂志,2009,30(5):337.) |
| [45] | CAO Minli, LI Sha, L ¨U Jianhong, et al. J Chin Clin Med Imaging,2009,20(6):479.(in Chinese)(曹敏丽,李莎,吕建红,等.中国临床医学影像杂志,2009,20(6):479.) |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%