多巴胺已经被广泛地用于材料的表面修饰改性,能够提高材料的生物相容性,赋予材料新的反应活性.为了考察多巴胺表面修饰胶原膜对其机械强度、湿热稳定性、亲水性和生物相容性的影响,对多巴胺自组装表面修饰胶原膜不同时间形成的膜材料进行研究,结果发现,经过多巴胺自组装表面修饰后,胶原保持完整的三股螺旋结构,膜材料的机械强度、湿热稳定性和亲水性均得到提高,而且成纤维细胞更易于在膜上粘附和增殖.
Doparnine has been widely used to surface modify materials due to its multi-functional reactivity and biocompatibility.Herein,in order to investigate whether the mechanical strength,hydrothermal stability,hydrophilic property and biocompatibility of collagen films are influenced,dopamine was.used to surface-modify collagen films,and then the films were characterized.Results showed that the triple helix structure of collagen remains intact,and mechanical strength,hydrothermal stability and hydrophilic property of the films are enhanced.Besides,the films can promote adhesion and proliferation of fibroblasts.
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