9,9-二(3-氨基-4-羟基苯基)呫吨的合成

应用化学, 2015, 32(1): 60-63. doi: 10.11944/j.issn.1000-0518.2015.01.140123

9,9-二(3-氨基-4-羟基苯基)呫吨的合成

1.江西师范大学化学化工学院南昌330022

2.江西师范大学化学化工学院南昌330022

3.江西师范大学化学化工学院南昌330022

4.江西师范大学化学化工学院南昌330022

基金项目: 江西省自然科学基金(20132BAB206031) the National Natural Science Foundation of China(21064003,51163008,21464007) the Natural Science Foundation of Jiangxi Province of China(20132BAB206031) 国家自然科学基金(20664001,51163008,21464007)

关键词：二(硝基羟基苯基)呫吨 , 二(氨基羟基苯基)呫吨 , 硝化反应 , 还原反应 , 水合肼

Preparation of 9,9-Bis (3-amino-4-hydroxyphenyl) xanthene

Keywords： bis (nitro-hydroxyphenyl) xanthene , bis (amino-hydroxyphenyl) xanthene , nitration reaction ,

以醋酸酐为溶剂,将9,9-二(4-羟基苯基)呫吨与浓硝酸在15℃左右发生硝化反应1.5h,形成中间体-9,9-二(3-硝基-4-羟基苯基)呫吨,产率为88.5％;继而以Pd/C为催化剂,80％的水合肼为还原剂,在乙醇和1,4-二.氧六环混合溶剂中,于70℃将中间体进行还原反应10 h,得到目标产物9,9-二(3-氨基-4-羟基苯基)呫吨,产率为90.8％,两步反应总收率为80.4％.中间体与目标化合物经NMR、FTIR和元素分析等确定了它们的结构.

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