基于水杨酰腙配体的二丁基锡配合物的合成、晶体结构、热稳定性及与DNA相互作用

应用化学, 2015, 32(5): 562-569. doi: 10.11944/j.issn.1000-0518.2015.05.140324

基于水杨酰腙配体的二丁基锡配合物的合成、晶体结构、热稳定性及与DNA相互作用

郑建华 ^1, , 刘俊 ^2, , 肖尧 ^3, , 戴玲林 ^4, , 李海洋 ^5, , 谭宇星 ^6, , 冯泳兰 ^7, , 蒋伍玖 ^8, , 庾江喜 ^9,

1.功能金属有机材料湖南省高校重点实验室,化学与材料科学系,衡阳师范学院湖南衡阳 421008

2.功能金属有机材料湖南省高校重点实验室,化学与材料科学系,衡阳师范学院湖南衡阳 421008

3.功能金属有机材料湖南省高校重点实验室,化学与材料科学系,衡阳师范学院湖南衡阳 421008

4.功能金属有机材料湖南省高校重点实验室,化学与材料科学系,衡阳师范学院湖南衡阳 421008

5.功能金属有机材料湖南省高校重点实验室,化学与材料科学系,衡阳师范学院湖南衡阳 421008

6.湖南师范大学化学化工学院长沙 410081

7.功能金属有机材料湖南省高校重点实验室,化学与材料科学系,衡阳师范学院湖南衡阳 421008

8.功能金属有机材料湖南省高校重点实验室,化学与材料科学系,衡阳师范学院湖南衡阳 421008

9.功能金属有机材料湖南省高校重点实验室,化学与材料科学系,衡阳师范学院湖南衡阳 421008

基金项目: 湖南省大学生研究性学习项目(cx1301) the National Students' Innovation and Entrepreneurship Training Program(201310546127) Scientific Research Fund of Hu'nan Provincial Education Department of China(No.14C0171).国家级大学生创新创业训练计划(201310546127) the Scientific & Technological Projects of Hu'nan Province of China(2013TZ2025,2014NK3086,2014FJ3060) Students Research Study Project of Hu'nan Province(cx1301) 湖南省教育厅基金项目(14C0171) 湖南省科技计划项目(2013TZ2025,2014NK3086,2014FJ3060)

关键词：有机锡配合物 , 合成 , 晶体结构 , 热稳定性 , DNA

Synthesis, Crystal Structure, Thermal Stability and DNA Interaction of the Dibutytin Complex Based on Salicylacylhydrazone

Keywords： organotin complex , synthesis , crystal structure , thermal stability , DNA

2-羰基丙酸水杨酰腙与二丁基氧化锡反应,合成了二丁基锡2-羰基丙酸水杨酰腙配合物,经元素分析、1 H NMR、13C NMR、IR、UV-Vis和X射线单晶衍射等技术手段表征分子结构,结构分析表明,该配合物晶体属四方晶系,锡与配位原子形成变形五角双锥构型的双核有机锡配合物,分子以Sn2O2四元环为中心对称.热分析结果表明,在空气氛下,配合物在103℃以下可稳定存在;研究了配合物在近生理条件下与DNA的相互作用,用紫外光谱、荧光光谱法及粘度法研究了配合物与鲱鱼精DNA的相互作用,结果表明,配合物与鲱鱼精DNA作用方式为插入结合.

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