肝素钠/聚乙烯醇复合水凝胶的制备与性能

应用化学, 2015, 32(12): 1358-1363. doi: 10.11944/j.issn.1000-0518.2015.12.150228

肝素钠/聚乙烯醇复合水凝胶的制备与性能

邓新旺 ^1, , 胡惠媛 ^2, , 罗仲宽 ^3, , 吴茂盛 ^4, , 周莉 ^5,

1.深圳大学化学与化工学院广东深圳518060

2.深圳大学化学与化工学院广东深圳518060

3.深圳大学化学与化工学院广东深圳518060

4.深圳大学化学与化工学院广东深圳518060

5.深圳大学化学与化工学院广东深圳518060

基金项目: Shenzhen Science and Technology Fund(JCYJ20140509172609151, JCYJ2013032910261471, JCYJ20120613112258764) 深圳市科学与技术基金资助项目(JCYJ20140509172609151,JCYJ2013032910261471,JCYJ20120613112258764)

关键词：肝素钠 , 聚乙烯醇 , 复合水凝胶 , 人工角膜 , 细胞粘附

Preparation and Properties of Heparin Sodium/Polyvinyl Alcohol Composite Hydrogel

Keywords： heparin sodium , polyvinyl alcohol , composite hydrogel , artificial cornea , cell adhesion

通过循环冷冻-解冻法,制成了肝素钠/聚乙烯醇(HS/PVA)复合水凝胶材料.探讨了不同质量分数肝素钠对复合水凝胶材料的可见光透过率、含水率、亲水性、力学性能以及肝素钠释放量的影响.结果表明,复合水凝胶的可见光透过率为92％以上,溶胀平衡的含水率为72％～ 78％,亲水性较纯PVA水凝胶有所提升,拉伸强度和断裂伸长率都稍有下降.细胞粘附实验结果表明,适量的肝素钠的释放可以达到减少细胞粘附的效果.这种HS/PVA复合水凝胶材料有望用作人工角膜中心区材料.

参考文献

[1]	王洋;刑春生;周星;王磊;韩宏光.人工角膜材料分类及材料表面改性和生物相容性的研究[J].中国组织工程研究,2012(16):2989-2996.
[2]	Xu FL;Li YB;Deng YP;Xiong J.Porous nano-hydroxyapatite/poly(vinyl alcohol) composite hydrogel as artificial cornea fringe: characterization and evaluation in vitro[J].Journal of biomaterials science,20084(4):431-439.
[3]	李娜;周伟;孙恒.人工角膜的研究进展[J].医学综述,2009(4):575-579.
[4]	许凤兰;李玉宝;李吉东;杨维虎.多孔纳米羟基磷灰石/聚乙烯醇复合水凝胶的表征[J].化学研究与应用,2005(5):599-602.
[5]	Jiang S;Liu S;Feng W.PVA hydrogel properties for biomedical application.[J].Journal of the mechanical behavior of biomedical materials,20117(7):1228-1233.
[6]	Jui-Yang Lai;Tsu-Pin Wang;Ya-Ting Li.Synthesis, characterization and ocular biocompatibility of potential keratoprosthetic hydrogels based on photopolymerized poly(2-hydroxyethyl methacrylate)-co-poly(acrylic acid)[J].Journal of Materials Chemistry: An Interdisciplinary Journal dealing with Synthesis, Structures, Properties and Applications of Materials, Particulary Those Associated with Advanced Technology,20125(5):1812-1823.
[7]	牛国光;朱思泉;郑欲东;张红斌;宋黎;杨槐.用于治疗白内障的人工晶体材料及表面修饰研究进展[J].化学通报（印刷版）,2008(1):10-16.
[8]	Dallas L.Rabenstein.Heparin and heparan sulfate: structure and function[J].Natural product reports,20023(3):312-331.
[9]	Gadea, J.L.;Cesteros, L.C.;Katime, I..Chemical-physical behavior of hydrogels of poly(vinyl alcohol) and poly(ethylene glycol)[J].European Polymer Journal,201311(11):3582-3589.
[10]	Kyritsis, A.;Spanoudaki, A.;Pandis, C.;Hartmann, L.;Pelster, R.;Shinyashiki, N.;Rodríguez Hernández, J.C.;Gómez Ribelles, J.L.;Monleón Pradas, M.;Pissis, P..Water and polymer dynamics in poly(hydroxyl ethyl acrylate-co-ethyl acrylate) copolymer hydrogels[J].European Polymer Journal,201112(12):2391-2402.
[11]	刘秀英;张超灿;徐卫林.甲苯胺蓝分光光度法测定肝素钠的研究[J].化学试剂,2009(4):271-274.

上一张下一张

计量

下载量()
访问量()

作者相关

文章评分

您的评分：
1

0%
2

0%
3

0%
4

0%
5

0%

材料期刊网