丹参素是中药丹参的水溶性化学成分之一，具有很多潜在的药理活性。以3，4-二羟基苯甲醛和乙酰甘氨酸为原料，经Erlenmeyer反应并开环得到α-乙酰氨基-β-（3，4-二乙酰氧基苯基）丙烯酸、盐酸水解制得β-（3，4-二羟基苯基）丙酮酸，再经乳酸片球菌1.2696静息细胞生物酶催化还原合成了天然右旋丹参素，总收率69.4%，丹参素对映体过量值97.5%。
Danshensu is one of water-soluble components in Chinese medicine Danshen(Salvia miltiorrhiza bunge) and has some potential pharmaceutical activities. Danshensu was prepared through chemoenzymatic synthesis starting from the Erlenmeyer condensation of 3,4-dihydroxybenzaldehyde and acetyl glycine and followed by ring opening reaction to give α-acetamino-β-(3,4-diacetoxylphenyl)acrylic acid. Hydrolysis of the substituted acrylic acid with hydrochloric acid gave β-(3,4-dihydroxyphenyl) pyruvate. Finally, Danshensu was obtained by enzymatic reduction of β-(3,4-dihydroxyphenyl) pyruvate with resting cells of pediococcus acidilactici. The overall yield is 69.4% and the optical purity of Danshensu is 97.5% ee.
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