铜催化苯甲酰胺有氧环化合成7-叔烷基异喹啉二酮

应用化学, 2016, 33(10): 1175-1181. doi: 10.11944/j.issn.1000-0518.2016.10.160127

铜催化苯甲酰胺有氧环化合成7-叔烷基异喹啉二酮

邓佑林 ^1, , 唐石 ^2, , 李立洋 ^3, , 付美玲 ^4, , 王良能 ^5, , 陈蓝艳 ^6, , 周上睿 ^7,

1.吉首大学化学化工学院湖南吉首416000

2.吉首大学化学化工学院湖南吉首416000

3.吉首大学化学化工学院湖南吉首416000

4.吉首大学化学化工学院湖南吉首416000

5.吉首大学化学化工学院湖南吉首416000

6.吉首大学化学化工学院湖南吉首416000

7.吉首大学化学化工学院湖南吉首416000

基金项目: the Research Innovation Program for Graduates of Jishou University(JGY201636) 湖南省研究生培养创新基地(2014KFXM06)Supported by the National Natural Science Foundation of China(21462017) 国家自然基金资助项目(21462017) the Hu'nan Innovation Base for the Graduate Student Training(2014KFXM06) 吉首大学科技处研究生科研项目(15JDY001) the Research Program for Graduates of Science and Technology Department of Jishou University(15JDY001) 吉首大学研究生科研创新项目资助(JGY201636)

关键词：叔烷基异喹啉二酮 , 苯甲酰胺 , 有氧环化 , 铜催化

Synthesis of 7-tert-Alkylated Isoquinolinedione via Copper-catalyzed Aerobic Cyclization of Benzamides

Keywords： tert-alkylated isoquinolindione , benzamide , aerobic cyclization , copper catalysis

发展了一种高效、简单的铜/空气催化体系催化的苯甲酰胺串联自由基环化合成7-叔烷基异喹啉二酮的反应.在廉价CuI存在下,空气环境中,N-烷基-N-甲基丙烯酰基苯甲酰胺与AIBN发生串联自由基加成/环化/碳碳偶联反应,以52％～73％的产率合成了一系列的7-取代异喹啉二酮.此研究为合成具有潜在药用价值的含氰取代异喹啉二酮提供了一条快速、简单、温和的构建途径.

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