采用分子量为1 500的聚乙二醇(PEG)为大分子引发剂,引发ε-己内酯开环聚合,合成了分子量为2 900、3 400、4 700的端羟基的聚己内酯-聚乙二醇-聚己内酯(PCEC)嵌段共聚物,并用异氰酸基丙基三乙氧基硅烷(IPTS)将该共聚物端羟基修饰.红外结果表明,该聚合物在3 440、1 732、1 242、1 106 cm-1等处有羟基、酯键、醚键的特征峰,与IPTS反应后在3 350 cm-1、1 531 cm-1处出现了N-H的伸缩振动峰和(N-H)+(C-N)的弯曲振动峰,证实了PCEC以及端基为三乙氧基硅基的PCEC结构.采用溶胶-凝胶法将该产物与生物玻璃前躯体进行反应,获得PCEC-CaO-SiO2-P2 O5有机-无机杂化材料.PCEC-CaO-SiO2-P2 O5杂化材料在模拟体液(SBF)中浸泡24 h后,表面就开始覆盖钙磷沉淀物.XRD测试结果表明,PCEC-CaO-SiO2-P2 O5杂化材料表面覆盖的沉淀物主要成分为羟基磷灰石,表面沉积物随着杂化材料中亲水性成分的增加而增加.力学性能测试表明,随着高分子中PEG含量的增加,PCEC-CaO-SiO2-P2O5有机-无机杂化材料的压缩模量从6.9 MPa上升到65 MPa.细胞毒性表明,PCEC-CaO-SiO2-P2 O5杂化材料对细胞没有明显的毒性.
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