采用火焰喷球法制备了组成为10Na2O-10CaO-80B2O3(wt%)和19Na2O-17CaO-64B2O3(wt%)的钠钙硼(NCB)玻璃(分别记为S1和S2)微球，通过pH计、XRD、SEM、SEM-EDS、FTIR和BET研究了两种微球原位转化为中空羟基磷灰石(HA)微球及对浸泡液酸碱度的影响，并以万古霉素为模型药物，进一步研究了中空 HA 微球的缓释性能。结果表明， S1-HA微球具有较大的空腔体积和较好的药物负载性能，其载药量和载药率分别达到13.5 mg/g和16.8%；而S2微球对浸泡液pH的影响相对较强， S2-HA微球呈现显著的层状结构，且具有较好的缓释性能，其缓释时间可达到60 h。
The Na-Ca-B glass microspheres with composition of 10Na2O-10CaO-80B2O3(wt%) and 19Na2O-17CaO- 64B2O3(wt%) were prepared (denoted by S1 and S2, respectively) by flame spray ball method. The in-situ transformation of the microspheres into hollow hydroxyapatite(HA) and the influence on the pH value of the soaking-liquid were inves-tigated by using pH meter, XRD, SEM, SEM-EDS, FTIR and BET measurements. In addition, the vancomycin was used as model drug to further investigate the sustained-release performance of hollow HA. The results indicate that S1-HA has larger cavity volume and better drug loading performance with 13.5 mg/g and 16.8% for its drug loading amount and effi-ciency, respectively. S2 microspheres can greatly influence the pH value of the soaking-liquid. Meanwhile, S2-HA present remarkable multilayered structure and better sustained-release performance with the release time of 60 h.
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