壳聚糖/有机锂皂石纳米复合材料的制备及抗菌性能研究

无机材料学报, 2016, 31(5): 479-484. doi: 10.15541/jim20150509

壳聚糖/有机锂皂石纳米复合材料的制备及抗菌性能研究

付海丽 ^1, , 张雯 ^2, , 张华 ^3, , 宋少波 ^4, , 李伟 ^5,

基金项目: 国家自然科学基金(51573135) 国家级大学生创新创业训练计划(201410058012)Nationall Natural Science Found of China(51573135) Tianjin City High School Science & Technology Fund Planning Project(20140305) National Training Programs of Innovation and Entrepreneurship for Undergraduates(201410058012) 天津市高等学校科技发展基金(20140305)

关键词：有机锂皂石 , 壳聚糖 , 抗菌机理 , 二次插层 , 纳米复合物

Preparation and Antibacterial Activity of Chitosan/Organic Laponite Nanocomposites

Keywords： organic laponite , chitosan , antibacterial mechanism , secondary intercalation , nanocomposites

采用离子交换法将季铵盐及壳聚糖插层到锂皂石层间,制备锂皂石基二次插层复合物.所制备的两种二次插层复合物的层间距相比于纯的锂皂石分别增加了0.276 nm和0.262 nm.用大肠杆菌(E.coli)和金黄色葡萄球菌(S.cereus)为模拟体系对二次插层复合物的抗菌性进行了检验,利用抑菌环和平板计数法测定两种二次插层复合物的抗菌能力.抗菌结果显示,细菌与两种复合物接触24 h后,锂皂石/十四烷基三甲基溴化铵/壳聚糖对大肠杆菌的抗菌率可达100％,对S.cereus的抗菌率可达85％以上,锂皂石/十六烷基三甲基溴化铵/壳聚糖对大肠杆菌和金黄色葡萄球菌的抗菌率均可达99％以上.采用扫描电镜法及β-半乳糖苷酶活性考察了两种复合物对大肠杆菌和金黄色葡萄球菌抑菌过程及机理,结果表明:复合物首先通过表面带的正电荷将表面带负电的细菌吸附到材料表面,随后借助有机物阳离子的疏水作用,穿透细菌细胞膜,从而达到杀菌效果.

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