本文提出了一种基于光电转换纳米复合物(NCs)的新型神经调控方式.NCs是TiO2纳米晶表面连接金纳米粒子的复合物,可产生光电流并有效引发神经细胞去极化.在405 nm光照射下,NCs产生的光电流比单一TiO2纳米晶产生的光电流强度显著提高.PC12细胞上的膜电位荧光探针和钙离子荧光探针测试结果显示,在405 nm光照下,经NCs处理的细胞发生去极化.在活体抗癫痫实验中进一步证明,NCs产生的光电流可明显减轻斑马鱼的癫痫发作.本研究结果表明NCs可进行神经调控,对神经疾病的治疗具有重要意义.
A novel noninvasive yet highly efficient neuromodulation method via photoelectric nanocomposites (NCs) Was proposed.The NCs were constructed by Au nanoparticles-attached TiO2 nanocrystals.Upon 405 nm light exposure,the photocurrent was enhanced when the pure TiO2 nanocrystals were modified with Au nanoparticles.It is evidenced that effective depolarization of NCs-treated neurons takes place upon 405 nm light illumination,certified by fluorescent dye test on PC12 cells.Furthermore,the NCs could remarkably remit the epilepsy seizures of zebrafishes,indicating that the NCs are potential candidates for curing neurological disorders.
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