生物医用钛合金植入体与骨细胞结合能力差一直是医学界面临的难题之一，表面形貌作为影响植入体生物相容性的重要因素，受到国内外学者的广泛研究。针对植入体表面微纳结构的国内外研究现状进行了叙述，重点介绍了植入体表面的微米结构、纳米结构、微纳米多级结构的制备及其对生物相容性的影响。综述表明：植入体表面合适的微米结构或纳米结构对细胞的行为表现出积极作用，能够增加植入体的生物活性和生物相容性；兼具微米与纳米多级结构表面的种植体表现出微米结构和纳米结构的协同效应，相对于单一的微米或纳米结构，能更好地促进骨整合。最后，针对医用钛合金植入体表面结构研究中存在的一些问题，指出了植入体表面结构的研究趋势。
ABSTRACT:The poor binding capacity between biomedical titanium alloy implant and osteoblasts is one of the difficult prob-lems in medical field. Surface topography, as an important factor, affects the biocompatibility of the implant, which attracts the widespread attention of researchers. The state-of-the-art of micro-nanostructure on implant was presented in this paper, and the specific conditions for preparation of micron structure, nanostructure and hierarchical micro/nanostructure on implant were in-troduced, as well as the effect on biocompatibility. The summary showed that the implant surface with suitable micron or nano structure had positive effect on cell behavior, and could increase its biological activity and biocompatibility. Implant with mul- ti-level surface structure had synergistic effect of micron structure and nanostructure compared to a single micron structure or nanostructure surface, which significantly improved the osseointegration. Finally, aiming at some problems or shortcomings in the research of medical titanium alloy implant, the research trend of structure surface on implant was proposed.
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