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  4. 激活基因的玻璃

无机材料学报, 2002, 17(5): 897-909. doi: 10.3321/j.issn:1000-324X.2002.05.001

激活基因的玻璃

L.L. Hench 1, , I. Xynos 2, , A. Edgar 3, , L. Buttery 4, , J. Polak 5, , 钟吉品 6, , 刘宣勇 7, , 常江 8,

1.英国伦敦大学皇家科技医学学院组织工程中心

2.英国伦敦大学皇家科技医学学院组织工程中心

3.英国伦敦大学皇家科技医学学院组织工程中心

4.英国伦敦大学皇家科技医学学院组织工程中心

5.英国伦敦大学皇家科技医学学院组织工程中心

6.中国科学院上海硅酸盐研究所,上海200050

7.中国科学院上海硅酸盐研究所,上海200050

8.中国科学院上海硅酸盐研究所,上海200050

关键词： 生物玻璃 , 基因活化 , 溶解硅 , 组织工程

Gene Activating Glasses

三十年前发现,生物玻璃能与骨形成骨键结合.这种特殊的材料已经有超过15年的临床应用,并有数以千计的成功病例.研究表明,骨的键合及骨再生和修复(骨形成作用)涉及玻璃表面的离子快速交换反应、生物活性表面反应层的成核和生长、由可溶硅和钙组成的临界浓度的离子溶解产物的释放.生物活性玻璃的分子生物学机理研究表明,它的生物活性响应看起来是由基因控制的.具有骨促进作用的A类生物活性玻璃通过直接对那些调节诱发细胞周期开始和进程的基因的直接控制,从而加强了其骨形成和促进作用.不能够形成新骨的细胞从细胞总体中被消除,这一特征是当成骨细胞在生物惰性材料或者B类生物活性材料培养时所没有的.骨前细胞细胞周期的基因调控生物学结果是成骨细胞的快速繁殖和分裂,这也导致了骨的迅速再生.对生物活性玻璃基因基础的理解,可以为设计新一代活化基因的玻璃材料、以及新一代活化基因的组织工程用生物降解支架材料提供重要的依据.如果我们能用玻璃激活基因,可以肯定,有一天我们就能用玻璃来控制基因.

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