对用于骨折内固定的β-偏磷酸钙晶须/左旋聚乳酸(β-CMPw/PLLA)复合材料在体外降解过程中强度的变化、分子量和微观形貌进行了初步研究.结果表明:在人体模拟体液(SBF)中浸泡,前8周材料的强度变化较小,25 wt%β-CMPw/75 wt%PLLA降解20周后的抗压强度值仍高达103 MPa 45 wt%β-CMPw/55 wt%PLLA降解12周后抗压强度约为初始值的88%.扫描电镜图表明,随降解时间的延长,因聚乳酸溶解而在样品中形成孔洞.在降解周期内,SBF溶液的pH值随β-CMPw/PLLA降解时间的延长基本保持稳定.凝胶渗透色谱检测结果表明,PLLA的数均相对分子质量和重均相对分子质量随降解时间的延长而降低,降解20周后数均相对分子质量约为20万,重均相对分子质量下降了32%.
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