采用自行设计的悬浮液热分散复合法,用硬脂酸(Sad)作为致孔剂,通过复合-沉析-浸溶-漂洗-干燥的工艺制备大孔聚磷酸钙/壳聚糖(CPP/CS)复合材料棒材.将复合悬液滴入凝固液中,经浸泡-漂洗-干燥的工艺制备CPP/CS微孔复合材料颗粒.用红外光谱及扫描电镜对复合材料进行了表征.实验表明,合成的复合材料中CS的氨基和CPP的P=O基生成了氢键,其形态结构致密均匀,大孔复合材料棒材的孔径为50～300 μm,孔隙率为71.13%;微孔复合材料颗粒的孔径为10～100 μm,孔隙率为40.76%.研究了2种工艺不同配比复合材料的细胞相容性,发现:大孔复合材料棒材的细胞相容性比微孔复合材料颗粒好,复合材料中随着CPP含量的增加,细胞相容性增加,当复合材料中CPP和CS的质量比为7/3时,复合材料的细胞相容性较好.CPP与CS复合可以提高其压缩强度,原料质量配比为CPP/CS=7/3时,复合材料的强度最高.
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