使用硬脂酸对羟基磷灰石表面进行改性,制备了纳米羟基磷灰石/聚碳酸酯(n-HA/PC)复合生物材料,利用透射电子显微镜(TEM)、红外光谱(FTIR)、X射线衍射(XRD)、扫描电子显微镜(SEM)等对羟基磷灰石和复合生物材料微观组成结构进行了表征.结果表明:弱结晶结构的纳米羟基磷灰石经表面改性后,硬脂酸通过离子键吸附在其表面,形成有效的有机包覆层;与聚碳酸酯复合时,通过氢键与聚合物结合,改善了n-HA与PC聚合物的界面相容性;制备的n-HA/PC复合材料与自然骨力学性能相匹配.
参考文献
| [1] | Hench L L,Wilson J.Surface-active biomaterials[J].Science,1984,226:630-636. |
| [2] | Suchanek W,Yoshimura M.Processing and properties of hydroxyapathe-base biomaterials for use as hard tissue replacement implants[J].J Mater Res,1998,13(1):94-117. |
| [3] | Abu Bakar M S,Cheang P,Khor K A.Tensile properties and microstructural analysis of spheroidized hydroxyapatite poly(etheretherketone)biocomposites[J].Materials Science and Engineering,2003,A345:55-63. |
| [4] | Suljovrujica E,lgnjatovilcb N,Uskokovi D.Gamma irradiation processing of hydroxyapatite/poly-L-lactide composite biomaterial[J].Radiation Physics and Chemistry,2003,67:375-379. |
| [5] | Hulbert S F,Bokros J C,Hench L L,et al.Ceramics in clinical applications,past,present and future[M]∥Vincenzini P,ed.High Tech Ceramics.Italy:Milan Press,1986:189-190. |
| [6] | Li Yubao,de Wijn J R,Klein C P A T,et al.Preparation and characterization of nanograde osteoapatite-like rod crystals[J].J Mater Sci:Materials in Medicine,1994,5:252-255. |
| [7] | 李玉宝.生物医学材料[M].北京:化学工业出版社,2003;27,41. |
| [8] | Bonfield W,Grympas M D,Tully A E,Bowman A J.Hydroxyapatite reinforced polyethylene a mechanically compatible implant material for bone replacement[J].Biomaterials,1981,2:185-186. |
| [9] | Ishaug-Riley S L,Crane G M,Gurlek A,et al.Ectopic bone formation by marrow stromal osteoblast transplantation using poly(DL-lactic-co-glycolic acid)foams implanted into the rat mesentery[J].J Biomed Mater Res,1997,36:1-8. |
| [10] | Dueheme P,Qiu Q.Bioactive ceramics:The effect of surface reactivity on bone formation and bone cell function[J].Biomaterials,1999,20:2287-2303. |
| [11] | 全大萍,廖凯荣,卢泽俭,等.聚DL-丙交酯/羟基磷灰石(PDLLA/HA)复合材料Ⅳ:HA表面处理及PDLLA界面作用研究[J].复合材料学报,2001,18(2):22-26.Quan Daping,Liao Kairong,Lu Zejian,et al.Poly(DL-lactide)/hydroxyapatite composite Ⅳ:Surface modification of hydroxyapatite and its effect on the interfacial interaction of the composites[J].Acta Materiae Compositae Sinica,2001,18(2):22-26. |
| [12] | 左奕,李玉宝,张翔,等.纳米复合支架结构与生物学性能[J].复合材料学报,2005,22(6):32-36.Zuo Yi,Li Yubao,Zhang Xiang,et al.Structure and biologic properties of nano-composite scaffold[J].Acta Materiae Compositae Sinica,2005,22(6):32-36. |
| [13] | 王学江,汪建新,李玉宝,等.常压下纳米级羟基磷灰石针状晶体的合成[J].高技术通讯,2000,10(11):92-94.Wang Xuejiang,Wang Jianxin,Li Yubao,et al.Preparation of nanograde hydroxyapatite needle-like crystals under normal atmospheric pressure[J].Chinese High Technology Letters,2000,10(11):92-94. |
| [14] | John L,Meyer J L,Fowler B O.Lattice defect in nonstoichiometric calcium hydroxyapatites:A chemical approach[J].Inorg Chem,1982,21:3029-3035. |
| [15] | Li Yubao.Synthesis and characterization of bone-like mineral;Macroscopic approach and microscopic emulation-biomaterials group research[D].Leiden:University of Leiden,1994;99-110. |
| [16] | Liu Qing,de Wijn J R,de Groot K,et al.Surface modification of nano-apatite by grafting organic polymer[J].Biomaterials,1998,19(11/12):1067-1072. |
| [17] | Montel G,Bonel G,Heugheubaert M,Trombe J C,Rey C.New concept in the composition,crystallization and growth of the mineral component of calcified tissues[J].J Crystal Growth,1981,53:74-99. |
| [18] | Pascalis E P,Betts F,DiCarlo E,Mendelsohn R,Boskey A L FTIR mierospectroscopic analysis of normal human cortical and trabecular bone[J].Calcif Tissue Int,1997,61;480-486. |
| [19] | Bragg L.The crystalline state,a general survey[M].London:Bell G and Sons,1919;189. |
| [20] | Klug H P,Alexander LE.X-ray diffraction procedures for polycrystallite and amorphous materials[M].2nd ed.New York:Wiley,1974:268-320. |
| [21] | Danilchenko S N,Kukharenko O G,Moseke C,Protsenko I Y,Sukhodub L F,Sulkio-Cleff B Determination of the bone mineral crystallite size and lattice strain from diffraction line broadening[J].Cryst Res Technol,2002,37(11):1234-1240. |
| [22] | Jarcho M.Calcium phosphate ceramics as hard tissue prosthetics[J].Clinic Orthop,1981,157:259-278. |
| [23] | 俞耀庭.生物医用材料[M].天津:天津大学出版社,2000:121. |
| [24] | Kawasaki T.Fundamental-study of hydroxyapatite high-performance liquid-chromatography 3:Direct experimental confirmation of the existence of 2 types of adsorbing surface on the hydroxyapatite crystal[J].J Chromatogr,1990,515:125-148. |
| [25] | Somasundaran P,Wang Y H C.Surface chemical characteristics and adsorption properties of apatite[M]//Misra D N,ed.Adsorption on and surface chemistry of hydroxyapatite.New York:Plenum Press,1984:129-149. |
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