研究了纳米羟基磷灰石/聚碳酸酯(n-HA/PC)生物复合材料在模拟体液(SBF)中的表面变化,并用傅里叶红外光谱(FTIR)、X射线衍射仪(XRD)和扫描电子显微镜(SEM)对材料的表面变化进行了分析.结果表明,n-HA/PC生物复合材料在模拟体液(SBF)中浸泡后,表面会沉积碳酸化羟基磷灰石(CHA),随着浸泡时间的延长,沉积层变厚,CHA晶体形貌变得规整.对n-HA/PC复合材料进行了细胞实验,通过四唑盐(MTT)检测和扫描电镜观察,表明n-HA/PC复合材料无细胞毒性,细胞形态正常,是一种有应用前景的可承力骨修复替代材料.
参考文献
[1] | Hench L L,Wilson J.Surface-active biomaterials[J].Science,1984,226:630-636. |
[2] | Suchanek W,Yoshimura M.Processing and properties of hydroxyapatite-base biomaterials for use as hard tissue replacement implants[J].J Mater Res,1998,13(1):94-117. |
[3] | Abu Bakar M S,Cheang P,Khor K A.Tensile properties and microstructural analysis of spheroidized hydroxyapatite poly(etheretherketone)biocomposites[J].Materials Science and Engineering,2003,A345:55-63. |
[4] | Suljovrujica E,Ignjatovilcb N,Uskokovi D.Gamma irradiation processing of hydroxyapatite/poly-L-lactide composite biomaterial[J].Radiation Physics and Chemistry,2003,67:375-379. |
[5] | Bonfield W,Grympas M D,Tully A E,Bowman A J.Hydroxyapatite reinforced polyethytene a mechanically compatible implant material for bone replacement[J].Biomatefials,1981,2:185-186. |
[6] | Ishaug-Riley S L,Crane G M,Gurlek A,et al.Ectopic bone formation by marrow stromal osteoblast transplantation using poly(DL-lactic-co-glycolic acid)foams implanted into the rat mesentery[J].J Biomed Mater Res,1997,36:1-8. |
[7] | Ducheme P,Qiu Q.Bioactive ceramics:The effect of surface reactivity on bone formation and bone cell function[J].Biomaterials,1999,20:2287-2303. |
[8] | 全大萍,廖凯荣,卢泽俭,等.聚DL-丙交酯/羟基磷灰石(PDLLA/HA)复合材料Ⅳ:HA表面处理及PDLLA界面作用研究[J].复合材料学报,2001,18(2):22-26.Quan Daping,Liao Kairong,Lu Zejian,et al.Poly(DL-lactide)/hydroxyapatite composite Ⅳ:Surface modification of hydroxyapatite and its effect on the interracial interaction of the composites[J].Acta Materiae Compositae Sinica,2001,18(2):22-26. |
[9] | 左奕,李玉宝,张翔,等.纳米复合支架结构与生物学性能[J].复合材料学报,2005,22(6):32-36.Zuo Yi,Li Yubao,Zhang Xiang,et al.Structure and biologic properties of nano-composite scaffold[J].Acta Materiae Compositae Sinica,2005,22(6):32-36. |
[10] | Copper S L.A comparison of the adsorption of three adhesive proteins to biomaterial surface[J].J Biomater Sci Poly Edn,1991,3(1):27-47. |
[11] | 赵文轸.材料表面工程导论[M].西安:西安交通大学出版社,1998:14-21. |
[12] | 石宗利,王彦平,戴刚,等.CPP/PLLA软骨组织工程支架复合材料初步研究[J].复合材料学报,2002,19(6):97-100.Shi Zongli,Wang Yanping,Dai Gang,et al.CPP/PLLA composites of scaffolds for tissue engineering[J].Acta Materiae Compositae Sinica,2002,19(6):97-100. |
[13] | Liu Qing,de Wijn J R,de Groot K,et al.Surface modification of nano-apatite by grafting organic polymer[J].Bonraterials,1998,19(11/12):1067-1072. |
[14] | Ducheyne P,Radin S,King L.The effect of calcium phosphate ceramic composition and structure on in vitro behavior Ⅰ:Dissolution[J].J Biomed Mater Res,1993,27;25-34. |
[15] | Radin S,Ducheyne P.The effect of calcium phosphate ceramic composition and structure on in vitro behavior 2:Precipitation dissolution[J].J Biomed Mater Res,1993,27:35-45. |
[16] | Montel G,Bonel G,Heugheubaert M,Trombe J C,Rey C.New concept in the composition,crystallization and growth of the mineral component of calcified tissues[J].J Crystal Growth,1981,53:74-99. |
[17] | Pascalis E P,Betts F,DiCarlo E,Mendelsohn R,Boskey A L.FTIR mlcrospectroscopic analysis of normal human cortical and trabecular bone[J].Calcif Tissue Int,1997,61:480-486. |
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