将成骨诱导前后的大鼠骨髓间充质干细胞与不同比例、不同孔径和不同孔隙率的β-TCP/PLLA材料复合,通过体内体外实验研究β-磷酸三钙/聚L-乳酸(β-TCP/PLLA)的成分、孔径和孔隙率等结构参数对复合材料在体内异位成骨能力的影响.结果表明,β-TCP/PLLA成分比为2:1,致孔剂含量为70%;孔径为200～450 μm的支架材料在体外更有利于细胞的生长、增殖以及分化.这种支架材料在裸鼠体内具有异位成骨的能力,成骨诱导后的大鼠骨髓间充质干细胞比没有诱导的细胞更适合作为种子细胞.
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