采用磷酸四钙和磷酸氢钙为磷灰石水泥(AC)粉末,5wt%硅酸钠水溶液为固化液,氯化钠为致孔剂,制备了掺杂钠元素的硅磷灰石水泥(s-AC)多孔支架用于骨缺损再生修复.结果显示:s-AC多孔支架的成分为含钠硅元素的磷灰石,支架大孔之间互相贯通,孔径在200～600 μm,孔隙率在58%～75%,抗压强度在1.6～3.8MPa的范围内.与AC相比,掺杂一定量的钠硅元素提高了s-AC支架在Tris-HCl溶液中的降解性.将s-AC多孔支架植入兔股骨缺损处,组织学分析结果显示:新生骨在支架材料的表面直接形成,并长入其中,相互贯通的多孔支架促进了新骨长入其内部.结果表明:s-AC支架具有优良的生物相容性、降解性和成骨性,将是一种优良的骨修复生物材料.
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