以十六烷基三甲基溴化铵(CTAB)为模板, 用溶胶?凝胶法合成了掺杂钙银介孔氧化硅凝胶(m-SCA)抗菌止血材料. 结果表明: m-SCA具有介孔结构, 比表面积为416 m2/g, 孔径在2 nm左右. 高比表面积的m-SCA具有很好的凝血功能, 能明显缩短血液的凝血酶原时间(PT)和部分凝血活酶时间(APTT). 含少量银的m-SCA对其凝血性能没有明显影响, 而m-SCA中的钙能促进凝血. 含银0.02wt%的m-SCA无细胞毒性, 对大肠杆菌有明显的抑制作用. 动物试验表明: m-SCA具有很好的止血性能, 能阻止兔耳伤口的流血并缩短其流血时间. m-SCA是一种有很好应用前景的抗菌止血材料.
An antibacterial hemostatic material of mesoporous silicon oxide gel doped with Ca and Ag (m-SCA) gel was fabricated by using cetyltrimethylammonium bromide(CTAB) as templates and Sol-Gel process. The results showed that m-SCA with mesoporous structure had the surface area of 416 m2/g and pore size of around 2 nm. The m-SCA with high surface area and good clotting function could significantly shorten the prothrombin time (PT) and activated partial thromboplastin time (APTT). The m-SCA containing a small quantity of Ag had no obvious effects on its clotting properties while Ca in m-SCA could promote clotting. The m-SCA doped 0.02wt% Ag without cytotoxicity had good antibacterial properties against E.coli. Animal experimental results showed that the m-SCA could control hemorrhage and shorten the bleeding time of rabbit ear wound, showing good hemostatic properties. It suggestes that the m-SCA is a good hemostatic material with antibacterial properties.
参考文献
| [1] | |
| [2] | |
| [3] | Bjorsesa K, Holst J. Various local hemostatic agents with different modes of action |
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