以CaCO3为模板,正硅酸四乙酯(TEOS)为硅源,用比较简单的方法制备了中空SiO2;然后将海藻酸钠嫁接在氨基化的中空SiO2表面;再利用海藻酸盐与钙离子的作用,在中空SiO2表面形成一个凝胶化层,制得海藻酸盐凝胶化的中空SiO2微球,粒径为1～2μm.采用FTIR、XRD、SEM、TEM和TGA等测试技术对微球进行表征.此微球成功地用于柔红霉素的载负和缓释,最大载负率和载药量分别为55.6%和27.8%;缓释结果表明,海藻酸盐凝胶化层的存在,能更有效控制柔红霉素缓慢的释放,这种凝胶化载体对药效强、毒性较大的药物有潜在的临床应用前景.
参考文献
| [1] | HE Junhui,CHEN Hongmin,ZHANG Lin.Inorganic Hollow Micro/Nanospheres[J].Prog Chem,2007,19:1488-1494(in Chinese).贺军辉,陈洪敏,张林.无机微/纳空心球[J].化学进展,2007,19:1488-1494. |
| [2] | Chen Jianfeng,Ding Haoming,Wang Jiexin,et al.Preparation and Characterization of Porous Hollow Silica Nanoparticles for Drug Delivery Application[J].Biomaterials,2004,25:723 -727. |
| [3] | LI Xiaoqing,CHAI Shigan,YANG Tingting,et al.Biomimetic Synthesis of Hybrid Silica Nanoparticles Mediated by Linear Polyamines[J].Chinese J Appl Chem,2009,26(6):633-636(in Chinese).李小青,柴仕淦,杨婷婷,等.线性聚胺介导的SiO2杂化纳米粒子的仿生合成[J].应用化学,2009,26(6):633-636. |
| [4] | He Xiaoxiao,Wang Kemin,Tan Weihong,et al.Bioconjugated Nanoparticles for DNA Protection from Cleavage[J].J Am Chem Soc,2003,125(24):7168-7169. |
| [5] | Fowler C E,Khushalani D,Mann S.Facile Synthesis of Hollow Silica Microspheres[J].J Mater Chem,2001,11 (8):1968-1971. |
| [6] | Wang Jingui,Li Feng,Chen Tiehong,et al.Silica Hollow Spheres with Ordered and Radially Oriented AminoFunctionalized Mesochannels[J].Chem Mater,2009,21 (4):612-620. |
| [7] | Fuchigami K,Taguchi Y,Tanaka M.Preparation of Hemispherical Hollow Silica Microcapsules with Different Affinity Surface by Using Spherical Vaterite Calcium Carbonate as Template[J].Polym Adv Technol,2007,18(11):946-952. |
| [8] | Ashtari P,He Xiaoxiao,Wang Kemin,et al.An Efficient Method for Recovery of Target ssDNA Based on Amino-modified Silica-coated Magnetic Nanoparticles[J].Talanta,2005,67 (3):548 -554. |
| [9] | Li Zhulai,Chen Peng,Xu Xiuzhi,et al.Preparation of Chitosan Sodium Alginate Microcapsules Containing ZnS Nanoparticles and Its Effect on the Drug Release[J].Mater Sci Eng C,2009,29(7):2250-2253. |
| [10] | Zhou Gentao,Yao Qizhi,Guan Yebin,et al.Controlled Crystallization of Unstable Vaterite with Distinct Morphologies and Their Polymorphic Transition to Stable Calcite[J].Eur J Mineral,2010,22:259-269. |
| [11] | An Yanqing,Chen Miao,Xue Qunji,et al.Preparation and Self-assembly of Carboxylic Acid-functionalized Silica[J].J Colloid Interface Sci,2007,311:507-513. |
| [12] | Yang J,Lee J,Kang J,et al.Hollow Silica Nanocontainers as Drug Delivery Vehicles[J].Langmuir,2008,24:3417-3421. |
| [13] | WANG Jiexin,WEN Lixiong,CHEN Jianfeng,et al.Study on a Novel Template Synthesis Method for Hollow Silica Nanospheres[J].Acta Chim Sin,2005,63:1298-1302(in Chinese).王洁欣,文利雄,陈建峰,等.新型球形纳米空心SiO2的模板合成方法研究[J].化学学报,2005,63:1298-1302. |
| [14] | SUN Qingshan,WU Xinglong,GUO Yuguo,et al.Preparation of ZnO Nanostructures by Thermal Degradation of Zinc Alginate Fibers[J].Acta Phys-Chim Sin,2008,24(12):2179-2184(in Chinese).孔庆山,吴兴隆,郭玉国,等.海藻酸锌纤维热降解法制备氧化锌纳米结构[J].物理化学学报,2008,24(12):2179-2184. |
| [15] | Simeonova M,Ivanova G,Encher V,et al.Physicochemical Characterization and In vitro Behavior of Daunorubicin-loaded Poly(butylcyanoacrylate) Nanoparticles[J].Acta Biomater,2009,5(6):2109-2121. |
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