研究了次氯化血红素在乙酸酐、氢溴酸体系中脱铁制备次卟啉的新方法.考察了反应时间、温度以及乙酸酐和氢溴酸与次氯化血红素的比例对反应产率的影响,讨论了其脱铁机理.实验结果表明,当次氯化血红素与氢溴酸和乙酸酐的摩尔比为1∶6.3∶61.2,温度为100℃,反应2h时,脱铁产率高达96.3％.合成了一系列金属次卟啉配合物,考察了溶剂对卟啉配合金属难易程度及金属离子对卟啉S带和Q带的影响.用电喷雾串联质谱(ESI-MS-MS)、UV-Vis和IR表征了目标产物的结构.
参考文献
| [1] | Zhou W Y,Hu B C,Liu Z L.Metallo-deuteroporphyrin Complexes Derived from Heme:a Homogeneous Catalyst for Cyclohexane Oxidation[J].Appl Catal A:Gen,2009,358(2):136-140. |
| [2] | LI Donghong,DIAO Junlin,LIU Jiancang.Preparation of Magnetic Canoparticles Loading Photosensitizer and Their Photodynamic Activity[J].Chinese J Appl Chem,2008,25(9):1065-1068(in Chinese).李东红,刁俊林,刘建仓.载光敏剂磁性纳米粉的制备及其光敏活性[J].应用化学,2008,25(9):1065-1068. |
| [3] | Sundararaman P.High-performance Liquid Chromatography of Vanadyl Porphyrins[J].Anal Chem,1985,57:2204-2206. |
| [4] | Higuchi T,Hirobe M.Four Recent Studies in Cytochrome P450 Modelings:a Stable Iron Porphyrin Coordinated by a Thiolate Lgand; Arobust Ruthenium Porphyrin-Pyridine N-Oxede Derivatives System; Polypeptide-Bound Iron Porphyrin;Application to Drug Metabolism Studies[J].J Mol Catal A:Chem,1996,113:403-422. |
| [5] | Martins R R L,Neves M G,Silvestre A J D,et al.Oxidation of Unsaturated Monoterpenes with Hydrogen Peroxide Catalysed by Manganese (Ⅲ) Porphyrin Complexes[J].J Mol Catal A:Chem,2001,172:33-42. |
| [6] | YANG Weijun,GUO Cancheng.Metalloporphyrins and Their Biomimetic Catalytic Oxidation for Alkanes[J].Chinese J Appl Chem,2004,21(6):541-545(in Chinese).阳卫军,郭灿城.金属卟啉化合物及其对烷烃的仿生催化氧化[J].应用化学,2004,21(6):541-545. |
| [7] | Fritsch C,Goerz G,Ruzicka T.Photodynamic Therapy in Dermatology[J].Arch Dermatol,1998,134:207-214. |
| [8] | Lvova L,Paolesse R,Natale C D,et al.Detection of Alcohols in Beverages:An Application of Porphyrin-Based Electronic Tongue[J].Sens Actuators B,2006,118:439-447. |
| [9] | Hayashi T,Aya T,Nnoguchi M,et al.Structural Consequences of Nickel Porphyrin Dimmers[J].Tetrahedron,2002,58(14):2803-2811. |
| [10] | Dobson D F,Saini S.Porphyrin-Modified Electrodes as Bionimetric Sensors for the Determination of Organohalide Pollutants in Aqueous Samples[J].Anal Chem,1997,69 (17):3532-3538. |
| [11] | Ponomarev G V.Formylporphyrins and Their Derivatives in the Chemistry of Porphyrins[J].Chem Heterocycl Compd,1994,,130:1444-1465. |
| [12] | Corwin A,Singh R.Equilibrium Constants for the Demetalation of Iron Porphyrins[J].J Org Chem,1963,28:2476. |
| [13] | Lbmberg R,Bloompield B,Caiger P,et al.Porphyrins with Formyl Groups V Isolation of Porphyrin from Heart Muscle and Determination of Its Haem Content[J].Aust J Exp Biol,1955,33:435. |
| [14] | Caughey W S,Alben J O,et al.Substituted Deuteroporphyrins.Ⅰ.Reactions at the Periphery of the Porphyrin Ring[J].JOrg Chem,1966,31:2631. |
| [15] | Sun C G,Hu B C,Zhou W Y,et al.Investigations on the Demetalation of Metalloporphyrins under Ultrasound Irrediation[J].Ultrason Sonochem,2010,18(2):501-505. |
| [16] | Espenson J H,Christensen R J.Kinetics and Mechanism of the Demetalation of Iron(Ⅲ) Porphyrins Catalyzed by Iron (Ⅱ)[J].Inorg Chem,1977,16(10):2561-2564. |
| [17] | WANG Lanzhi,SHE Yuanbin.Spectroscopic Analysis of Substituted Tetraphenylperphyrin Iron,Manganese,Cobalt,Copper and Zinc Complexes[J].Spectrosc Spectr Anal,2008,28(10):2312-2317 (in Chinese).王兰芝,余远斌.取代金属(铁、锰、钴、铜、锌)卟啉的光谱分析[J].光谱学与光谱分析,2008,28(10):2312-2317. |
| [18] | Nascimento E do,Silva G de F,Caetano F A,et al.Partially and Fully β-Brominated Mn-Porphyrins in P450 Biomimetic Systems:Effects of the Degree of Bromination on Electrochemical and Catalytic Properties[J].J Inorg Biochem,2005,99:1193-1204. |
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