以H22肝癌的balb/c荷瘤小鼠为动物模型,考察了紫杉醇纳米胶束、紫杉醇注射液和生理盐水对小鼠肿瘤的抑制效果.紫杉醇注射液组、紫杉醇纳米胶束低剂量组和紫杉醇纳米胶束高剂量组在给药后10 d的肿瘤相对体积抑制率分别为22％、49％和67％,瘤重抑制率分别为29％、45％和47％；蛋白表达检测结果显示,紫杉醇纳米胶束组呈现p53的高表达和bcl-2的低表达,说明紫杉醇纳米胶束对小鼠H22肝癌的抑制作用强于紫杉醇注射液.
参考文献
| [1] | WANG Xiaojun,XU Xiaoyi,LIU Guojin,et al.Inhibition of the Proliferation of Lewis Lung Cancer Cells by PEG-PLA-paclitaxel Conjugate Micelles Nanometer Particle[J].Guangdong Med J,2007,28 (2):175-177 (in Chinese).王晓军,徐效益,刘国津,等.化学键合紫杉醇纳米微粒对Lewis肺癌细胞株的增殖抑制作用[J].广东医学,2007,28(2):175-177. |
| [2] | Rowinsky E K,Donehower R C.Drug-therapy-paclitaxel (taxol)[J].New Engl J Med,1995,332:1004-1014. |
| [3] | Kwon G S,Kaoka K.Block Copolymer Micelles as Long Circulating Drug Vehicles[J].Adv Drug Delivery Rev,1995,16:295-309. |
| [4] | Lee J,Cho E C,Cho K.Incorporation and Release Behavior of Hydrophobic Drug in Functionalized Poly (D,L-lactide)-block-poly(ethylene oxide) Micelles[J].J Controlled Release,2004,94 (3):323-335. |
| [5] | JING Xiabin,XIE Zhigang,LV Changhai,et al.Amphiplilic Triblok Copolymer-paclitaxel Conjugated and Synthesis Methods:CN,200610131690.X[P],2007-05-16(in Chinese).景遐斌,谢志刚,吕常海,等.两亲性三嵌段共聚物-紫杉醇键合药及其合成方法:中国,200610131690.X[P],2007-05-16. |
| [6] | He Min,Wang Kaiyu,Zhang Yu.Immunocytochemical Identification and Localization of Diffuse Neuroendocrine System (DNES) Cells in Gastrointestinal Tract of Channel Catfish (Ictalurus punctatus)[J].Agric Sci China,2009,8 (2):238-243. |
| [7] | Fromes Y,Gounon P,Veitia R,et al.Influence of Microtubule-associated Proteins on the Differential Effects of Paclitaxel and Docetaxel[J].J Protein Chem,1996,15(4):377-388. |
| [8] | DENG Jian,LIU Yunpeng.Progress of Bcl-2,Bax in Gastric Cancer[J].Chinese J Modern Drug Appl,2007,12(11):101-102(in Chinese).邓俭,刘云鹏.Bcl-2、Bax在胃癌中的研究进展[J].中国现代药物应用,2007,12(11):101-102. |
| [9] | Buchholz T A,Garg A K,Chakravarti N,et al.The Nuclear Transcription Factor B/bcl-2 Pathway Correlates with Pathologic Complete Response to Doxorubicin-based Neoadjuvant Chemotherapy in Human Breast Cancer[J].Clin Cancer Res,2005,11 (11):8398-8402. |
| [10] | Nayak S K,Panesar P S,Kumar H.p53-Induced Apoptosis and Inhibitors of p53[J].Current Medicinal Chem,2009,16(21):2627-2640. |
| [11] | Mercer W E.Cell Cycle Regulation and the p53 Tumor Suppress or Protein[J].Crit Rev Eukaryot Gene Expr,1992,(2):251-263. |
| [12] | Mazzatti D J,Lee Y J,Helt C E.p53 Modulates Radiation Sensitivity Independent of p21 Transcriptional Activation[J].Am J Clin Oncol,2005,28(1):43-50. |
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