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研究了一株药用红树内生真菌Penicillium sp.(ZZF29#)的次级代谢产物.用硅胶柱层析、制备薄层层析和重结晶等方法,从该菌发酵液的乙酸乙酯相中分离获得8种单体化合物,运用现代波谱技术并与文献数据对照,鉴定其结构分别为:环(苯丙-丙)二肽(1)、环(苯丙-甘)二肽(2)、环(苯丙-苯丙)二肽(3)、环(苯丙-酪)二肽(4)、大黄素(5)、大黄素甲醚(6)、麦角甾醇(7)和过氧化麦角甾醇(8).

参考文献

[1] Blunt J W,Copp B R,Munro M H G,et al.Marine Natural Products[J].Nat Prod Rep,2006,23:26-78.
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[3] Wei M Y,Zhang X L,Li S D,et al.A New Dihydroisocoumarin with an Isoprenyl Group from the Endophytic Fungus Cephalosporium sp.[J].Chem Nat Compd,2010,46(3):340-342.
[4] WANG Shuangming,TAN Ninghua,YANG Yabin,et al.Cyclodipeptides from the Roots of Panax Notoginseng[J].Nat Prod Res Dev,2004,16(5):383-386(in Chinese).王双明,谭宁华,杨亚滨,等.三七环二肽成分[J].天然产物研究与开发,2004,16(5):383-386.
[5] WU Xiongyu,LIN Yongeheng,FENG Shuang,et al.Studies on the Secondary Metabolite of Mangrove Endophytic Fungus No.1356 from the South China Sea[J].J Trop Oceanogr,2001,20(4):80-86(in Chinese).吴雄宇,林永成,冯爽,等.南海红树林内生真菌1356#代谢产物的研究[J].热带海洋学报,2001,20(4):80-86.
[6] ZHU Feng,LIN Yongcheng,ZHOU Shining,et al.Metabolites of Mangrove Endophytic Fungus No.2534 from the South China Sea[J].Acta Sci Nat Sun Yatsen,2003,42(1):52-54(in Chinese).朱峰,林永成,周世宁,等.南海红树林内源真菌2534号代谢产物的研究[J].中山大学学报(自然科学版),2003,42(1):52-54.
[7] SHAO Changlun,HU Guping,YANG Ruiyun,et al.Secondary Metabolites of Mangrove Endophytic Fungus B77 in the South China Sea[J].Acta Sci Nat Sun Yatsen,2008,47(1):56-58(in Chinese).邵长伦,胡谷平,杨瑞云,等.南海红树林内源真菌B77次级代谢产物研究[J].中山大学学报(自然科学版),2008,47(1):56-58.
[8] Aly A H,Edrada-Ebel R,Wray V,et al.Bioactive Metabolites from the Endophytic Fugus Ampelomyces sp.Isolated from the Medicinal Plant Urospermun Picroides[J].Phytochemistry,2008,69(8):1716-1725.
[9] ZHU Feng,CHEN Guangying,LIN Yongcheng,et al.Metabolites Produced by Mangrove Endophytic Fungi(No.2526 and No.1850) from the South China Sea[J].J Liaoning Normal Univ,2005,28(3):313-316(in Chinese).朱峰,陈光英,林永成,等.南海红树林内源真菌编号2526和编号1850代谢产物的研究[J].辽宁师范大学学报,2005,28(3):313-316.
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