以壳聚糖和甲基丙烯酸为原料,硝酸铈铵为引发剂,合成了不同接枝率的壳聚糖-g-聚甲基丙烯酸(CS-g-PMAA),用FTIR、1H NMR和元素分析表征了产物的结构,以柠檬酸三钠和戊二醛为交联剂制备了具有核壳结构的CS-g-PMAA载药体系.用UV/Vis检测了CS-g-PMAA粒子对模型药物的释放行为.结果表明,CS-g-PMAA接枝率为12.21％时药物释放速率最慢,其在pH=1.8介质中药物累积释放量(11 h)为44.18％,而壳聚糖粒子的累积释放量高达65.24％,即接枝改性壳聚糖粒子对药物的缓慢控制释放性能较好；CS-g-PMAA粒子的释药行为还依赖于介质的pH值和盐浓度,在低pH值和低盐浓度下,药物释放速率较快；酶环境下由于载体材料的降解使药物释放速率加快.分析了不同条件下CS-g-PMAA载药粒子中药物的释放机理.
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