将2-巯基-5-取代基-1,3,4-噻二唑经与β-氯苯丙酮取代、盐酸羟胺肟化和氯甲基(口恶)二唑醚化,合成了6种3-(5-取代基-1,3,4-噻二唑-2-硫代基)-1-苯基丙酮-O-(5-苯基-1,3,4-(口恶)二唑-2-甲基)肟醚化合物(4a～4f),用1 H NMR、IR、MS和元素分析表征了其结构.用MTT法测试了6种目标化合物对人黑色素瘤细胞株B16、人白血病细胞株HL60和人肝癌细胞株SMMC-7721的体外细胞毒活性.测试结果表明,部分化合物对3种癌细胞具有潜在的体外生长抑制活性.
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