以L-苯丙氨酸(L-Phe)、L-色氨酸(L-Trp)和L-亮氨酸(L-Leu)3种常见的氨基酸为手性源,经过酯化、缩合等步骤制备3种手性功能单体AAc-L-Phe(AAc:丙烯酸)、AAc-L-Trp和AAc-L-Leu,其结构经过IR、1H NMR确证.并将手性单体AAc-L-Phe与温敏材料N-异丙基丙烯酰胺(NIPAam)共聚,制备了手性共聚物P (NIPAam-co-AAc-L-Phe),结构经IR确证,示差扫描量热分析测试证明其具有温敏性.这些手性功能单体有可能用于制备环境响应性手性高分子聚合物.
参考文献
| [1] | YOU Qidong,LIN Guoqiang.Chiral Drugs——Research and Application[M].Beijing:Chemical Industry Press,2003:26-48(in Chinese).尤启冬,林国强.手性药物——研究与应用[M].北京:化学工业出版社,2003:26-48. |
| [2] | Maier N M,Franco P,Lindner W.Separation of Enantiomers:Needs,Challenges,Perspectives[J].J Chromatogr A,2001,906(1/2):3-33. |
| [3] | Francotte E R.Enantioselective Chromatography as a Powerful Alternative for the Preparation of Drug Enantiomers[J].J Chromatogr A,2001,906(1/2):379-397. |
| [4] | LI Li,ZI Min,REN Zhaoxing,et al.The Development of Chiral Stationary Phase in Gas Chromatography[J].Prog Chem,2007,19(2/3):393-403(in Chinese).李莉,字敏任朝兴,等.气相色谱手性固定相研究进展[J].化学进展,2007,19(2/3):393-403. |
| [5] | Jang H K,Jee H K,Jonggeon J,et al.Optical Resolution of Alpha-amino Acids Through Enantioselective Polymeric Membranes Based on Polysaccharides[J].J Membr Sci,2003,213(1/2):273-283. |
| [6] | WANG Jinfang,ZHOU Liangmo,LIU Xueliang,et al.Effect of Functional Monomer on Chiral Separation Ability of Molecular Imprinted Chiral Stationary Phase[J].Acta Chim Sin,2000,58(3):351-355(in Chinese).王进防,周良模,刘学良,等.功能单体对分子烙印手性固定相手性拆分能力的影响[J].化学学报,2000,58(3):351-355. |
| [7] | Bernal J L,Toribio L,Nozal M J.Separation of Antifungal Chiral Drugs by SFC and HPLC:A Comparative Study[J].J Biochem Biophys Methods,2002,54(1/3):245-254. |
| [8] | HOU Changjun,ZHOU Xuesong,HUO Danqun,et al.Development of Structural Modification and Performance Research of NIPA Series Thermosensitive Hydrogels[J].Mater Rev,2008,22 (7):36-37(in Chinese).侯长军,周雪松,霍丹群,等.NIPA系温敏凝胶结构改性及性能研究进展[J].材料导报,2008,22(7):36-37. |
| [9] | Winnik F M.Fluorescence Studies of Aqueous-solutions of Poly (N-isopropylacrylamide) Below and Above Their Lcst[J].Macromolecules,1990,23(1):233-242. |
| [10] | Schild H G,Tirrell D A.Microscalorimetric Detection of Lever Critical Solution Temperature in Aqueous Polymer Solution[J].J Phys Chem,1990,94(10):4352-4356. |
| [11] | Sakamoto C,Okada Y,Kanazawa H,et al.Temperature-and pH-responsive Aminopropyl-silica Ionexchange Columns Grafted with Copolymers of N-Isopropylacrylamide[J].J Chromatogr A,2004,1030(1/2):247-253. |
| [12] | Xie R,Chu L Y,Chen W M,et al.Characterization of Microstructure of Poly (N-isopropylacrylamide)-grafted Polycarbonate Tracketched Membranes Prepared by Plasma-graft Pore-filling Polymerization[J].J Membr Sci,2005,258(1/2):157-166. |
| [13] | Kaori K,Toshiaki S,Akira D.Enantiomeric Separation Using Temperature-responsive Chiral Polymers Composed of Valine Diamide Derivatives in Aqueous Liquid Chromatography[J].J Chromatogr A,2003,1012(1):47-56. |
| [14] | Wang D X,Zhang X X,Zhang J L,et al.Separation and Recognition of the Enantiomers of Trans Arylcyclopropanecarboxylic Acids and Their Amide and Nitrile Derivatives on Polysaccharide Stationary Phases[J].Chromatogr,2007,65 (5/6):343-348. |
| [15] | WANG Xiaodong,YAO Jinshui,WEi Mingxing,et al.Enantioselection and Development in Chiral Stationary Phase Based on Amino Acid[J].ChineseJ Org Chem,2006,26(7):912-921(in Chinese).王晓东,姚金水,魏明星,等.手性识别及氨基酸类手性固定相的研究进展[J].有机化学,2006,26(7):912-921. |
| [16] | WANG Qingdong.The Synthesis and Biological Assay of Ethyl L-α-Amino Acid Ester[D].Shanghai:Shanghai Normal University,2007(in Chinese).王庆东.L-α-氨基酸衍生物的合成与生物活性测定[D].上海:上海师范大学,2007. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%