三(o-溴苄基)锡吡咯烷基二硫代甲酸酯的合成、结构及体外抗癌活性

应用化学, 2014, 31(3): 285-289. doi: 10.3724/SP.J.1095.2014.30212

三(o-溴苄基)锡吡咯烷基二硫代甲酸酯的合成、结构及体外抗癌活性

张复兴 ^1, , 邝代治 ^2, , 冯泳兰 ^3, , 王剑秋 ^4, , 庾江喜 ^5, , 蒋伍玖 ^6, , 朱小明 ^7,

基金项目: 湖南省自然科学基金项目(11JJ3021) the Construct Program of the Key Discipline in Hunan Province and the Foundation of Key Laboratory of Functional Organometallic Materials,University of Hunan Province 湖南省重点学科基金和湖南省高校重点实验室开放基金湖南省高校创新平台开放基金项目(12K124) the Open Fund Project of Key Laboratory in Hunan Universities(12K124) Hunan Provincial Natural Science Foundation of China(11JJ3021)

关键词：三(o-溴苄基)锡吡咯烷基二硫代甲酸酯 , 合成 , 结构 , 抗肿瘤活性

Synthesis, Structure and Antitumor Activity of Tri (o-bromobenzyl) tin Dithiotetrahydropyrrolocarbamate

Keywords： tri (o-bromobenzyl) tin dithiotetrahydropyrrolocarbamate , synthesis , structure , antitumor activity

利用三(o-溴苄基)溴化锡与吡咯烷基二硫代甲酸钠反应,合成了三(o-溴苄基)锡吡咯烷基二硫代甲酸酯.用X射线单晶衍射测定了其晶体结构,化合物为三斜晶系,空间群P1,晶体学参数a=0.91354(11) nm,b=1.07313(13) nm,c=1.52677(18) nm,α =75.440(6)°,β=89.499(6)°,γ=72.515(7)°,V=1.3781(3) nm3,Z=2,Dc=1.868 g/cm3,μ(MoKα) =54.43 cm-1,F(000) =752,R1=0.0320,wR2=0.0765.化合物中的锡原子为四配位畸变四面体构型.对其结构进行量子化学从头计算,探讨了配合物的稳定性、分子轨道能量以及部分前沿分子轨道的组成特征.测定了配合物体外抗癌活性.

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