以N-羟甲基丙烯酰胺和苯酚类化合物为原料,合成了N-(2-羟基-3..丙烯酰胺甲基-4,6-二甲基苄基)丙烯酰胺(HMABA)、N-(2-羟基-3-丙烯酰胺甲基-4,5-二甲基苄基)丙烯酰胺(AMHBA)、N-(3,5-二甲基-4-羟基苄基)丙烯酰胺(MHBA)、N-(3,6-二甲基-4-丙烯酰胺甲基-2-羟基苄基)丙烯酰胺(MAHBA)和N-(2-甲氧基-4-甲基-5-丙烯酰胺甲基苄基)丙烯酰胺(MMABA)5个类辣素结构的丙烯酰胺衍生物.通过红外光谱(IR)、核磁波谱(1H NMR)、质谱(HR-MS)和元素分析对化合物的结构进行了表征.抑菌试验表明,HMABA对金黄色葡萄球菌和大肠杆菌的抑制效果最好,最低抑菌浓度均可达0.125 g/L.将此5个化合物作为防污剂制备海洋防污涂料,120 d的实海结果表明,基本无污损海生物附着.
参考文献
[1] | Bauer R S.Epoxy Resin,ACS Symposium Series[M].Washington DC:American Chemical Society,1985:931-961. |
[2] | QIAN Junmin,LI Xuxiang.Modification of Epoxy Resin[J].Eng.Plast Appl.,2001,29(10):50-53(in Chinese).钱军民,李旭祥.环氧树脂改性研究进展[J].工程塑料应用,2001,29(10):50-53. |
[3] | ZHAO Zhichao,YUAN Caideng,XU Tao,et al.Environmentally Friendly Epoxy Coating[J].Thermoset Resin,2005,20 (6):32-35(in Chinese).赵志超,袁才登,徐涛,等,环保型环氧树脂涂料[J].热固性树脂,2005,20(6):32-35. |
[4] | Takahirookamatsu,Mitsukazuochi.Effect on the Toughness and Adhesion Properties of Epoxy Resin Modified with Silylcrosslinked Urethane Microsphere[J].Polymer,2002,43(3):721-730. |
[5] | CONG Weiwei,YU Liangmin,ZHAO Haizhou,etal.N,N′-Dibutyl Dithio Oxymethyl Acrylamide,Antibacterial and Antifouling Properties[J].Paint Ind,2010,9(40):9-15(in Chinese).丛巍巍,于良民,赵海洲,等.Ⅳ,Ⅳ′-二丁氧基甲基二硫代二丙烯酰胺的合成、抑菌和防污性能研究[J].涂料工业,2010,9(40):9-15. |
[6] | Oommen S,John A R,Stinivas G,et al.Allicin (from garlic) Induces Caspase-mediated Apoptosis in Cancer Cells[J].Physiol Mol Plant Pathol,2004,65 (2):79. |
[7] | JIN Yong,LI Jun,YAO Hongwei,et al.Pepper Extract Inflammatory and Analgesic Effects[J].Anhui Med Univ,2001,36 (6):430-431 (in Chinese).金涌,李俊,姚宏伟,等.辣椒提取物的抗炎镇痛作用[J].安徽医药大学学报,2001,36(6):430-431. |
[8] | Kenneth J Fischer.Marine Organism Repellent Covering for Protection of Underwater Objects and Method of Applying Same:US,5226380[P],1993. |
[9] | James L Watts.Antifouling Coating Composition Containing Capsaicin:US,5397385[P],1995. |
[10] | Hamanok,Nagatak.Naimal Repdling Aqueous Coating Composition:JP,6219906[P],1994. |
[11] | Wang J L,Peng Z H,Zhou S Z,et al.A Study of Pungency of Capsaicinoid as Affectd by Their Molecular Structure Alteration[J].Sci Res,2011,2:109-115. |
[12] | PENG Bixian,WANG Junlian,PENG Zhenghong,et al.Synthetic Capsaicin Homologues,Spiciness and Antifouling Properties of Marine Organisms[J].Sci China:Chem,2011,41 (10):1464-1654(in Chinese)彭必先,王俊莲,彭争宏,等.辣椒素同系物合成、辣度及海洋生物防污性能研究[J].中国科学:化学,2011,41(10):1464-1654. |
[13] | XU Huanzhi,YU Liangmin,ZHANG Zhiming,etal.A Side-chain Hanging Pepper Rings Acrylamide Resin and Its Preparation Method and Application:CN,1624017[P],2005-6-8 (in Chinese).徐焕志,于良民,张志明,等.一种侧链悬挂胡椒环的丙烯酰胺树脂及其制备方法和应用:CN,1624017A[P],2005-6-8. |
[14] | CHEN Sihao,XU Zicheng,XU Jingli,et al.Synthesis of Capsaicin:CN,1982287A[P],2007(in Chinese).陈思浩,徐子成,徐菁利,等.辣素的合成方法:CN,1982287A[P],2007. |
[15] | MurainaI A,Picard J,Eloff J N.Development of a Reproducible Method to Determine Minimum Inhibitory Concentration (MIC) of Plant Extract Against a Slow-growing Mycoplasmas Organism[J].Phytomedicine,2009,16(2):262-264. |
[16] | GB/T 5370-85,Antifouling Panels in Shallow Submergence[S]. |
[17] | XU Huanzhi,YU Liangmin,LI Changcheng,et al.Capsaicin Derivatives and Their Inhibitory Activity Closterium[J].Chinese J Appl Chem,2007,24(8):911-916(in Chinese).徐焕志,于良民,李昌诚,等.辣素衍生物的合成及其对新月菱形藻的抑制活性[J].应用化学,2007,24(8):911-916. |
[18] | Pernak A,Skrzypczak A.3-Alkylthiomethyl-l-ethylimidazolium Chlorides Correlation between Critical Micelle Concentrations and Minimum Inhibitory Concentrations[J].Eur J Med Chem,1996,31 (11):901-903. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分:
-
10%
-
20%
-
30%
-
40%
-
50%