手性配体交换毛细管电泳在氨基酸手性分析中的应用研究进展

色谱 , 2016, (1): 21-27. doi: 10.3724/SP.J.1123.2015.05038

手性配体交换毛细管电泳在氨基酸手性分析中的应用研究进展

木肖玉 ^1, , 齐莉 ^2, , 苏圆 ^3, , 乔娟 ^4, , 陈义 ^5,

1.中国科学院化学研究所，中国科学院活体分析化学重点实验室，北京 100190; 中国科学院大学，北京 100049

2.中国科学院化学研究所，中国科学院活体分析化学重点实验室，北京 100190

3.中国科学院化学研究所，中国科学院活体分析化学重点实验室，北京 100190; 山东农业大学，山东泰安 271018

4.中国科学院化学研究所，中国科学院活体分析化学重点实验室，北京 100190

5.中国科学院化学研究所，中国科学院活体分析化学重点实验室，北京 100190

基金项目: 国家自然科学基金项目(21175138，21321003)．@@@@Project of the National Natural Science Foundation of China( Nos．21175138，21321003)．

关键词：手性配体交换毛细管电泳 , D,L-氨基酸 , 手性分析 , 综述

Development of chiral ligand exchange capillary electrophoresis for enantioseparation of D,L-amino acids

Keywords： chiral ligand exchange capillary electrophoresis( CLE-CE) , D,L-amino acids , enantioseparation , review

氨基酸的手性分析在生命科学中具有重要的研究意义。手性配体交换毛细管电泳法作为常用的氨基酸的手性分析方式之一，具有高效、快速、样品迁移顺序可调等优点，引起了研究者们极大的兴趣。本文主要综述了近年来手性配体交换毛细管电泳法在氨基酸的手性分析中的应用研究进展。

Enantioseparation of D,L-amino acids is of great significance in life science. As one of the most useful methods,chiral ligand exchange capillary electrophoresis possesses many advantages,including high efficiency,fast speed and tunable migration order,and it has attrac-ted great research interest. This review summarizes the development of chiral ligand exchange capillary electrophoresis for enantioseparation of D,L-amino acids in recent years.

参考文献

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