手性金属-有机骨架材料（ metal-organic frameworks，MOFs）作为一种新型的功能材料，因其具有高比表面积、丰富的拓扑结构、持久性的孔结构以及可修饰的孔道表面等特点，在对映选择性催化和手性分离方面有着广阔的应用前景。本文将一种单手螺旋三维金属-有机骨架材料[｛Cu（sala）｝n]（H2sala=N-（2-hydroxybenzyl）-L-ala-nine）与全戊基-β-环糊精混合，制备了新型毛细管气相色谱固定相。为了考察手性 MOF 是否能够增强全戊基-β-环糊精的手性分离能力，分别用不同的固定相制备了3根手性柱用于对比：柱 A（[｛Cu（ sala）｝n ]）、柱 B（全戊基-β-环糊精）和柱 C（[｛Cu（ sala）｝n ]+全戊基-β-环糊精）。比较了柱 A、柱 B 和柱 C 对相同手性化合物的拆分能力，结果表明柱 C具有更好的手性选择性和更高的分辨能力，证实使用 MOF[｛Cu（ sala）｝n ]能够提高全戊基-β-环糊精的对映选择分离能力。
Metal-organic frameworks ( MOFs ) as a new generation of functional molecular materials,have broad application prospects in enantioselective catalysis and chiral separation areas due to their unusual properties,such as high surface area,rich topologies,permanent microporous,availability of outer-surface modification and so on. A single-handed helical three-dimensional metal-organic framework material[{Cu(sala)}n](H2sala=N-(2-hydroxybenzyl)-L-alanine)was incorporated with peramylated β-cyclodextrin for the preparation of novel capil-lary gas chromatography stationary phase. To investigate whether the use of a chiral MOF can enhance enantioseparation on peramylated β-cyclodextrin,three chiral columns were fabricated using different stationary phases for comparison,including column A([{Cu(sala)}n]),col-umn B(peramylated β-cyclodextrin)and column C([{Cu(sala)}n]+peramylated β-cyclodex-trin). The results of comparing the resolving abilities of the three columns for the same chiral compounds demonstrated that column C showed better enantioselectivity and higher resolution. The use of MOF[{Cu( sala)}n ]can improve enantioseparation on peramylated β-cyclodextrin.
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