手性现象在自然界中广泛存在，手性分离在药物研发、农用化学、药理学、环境科学和生物学等诸多领域具有重要意义。手性金属有机骨架化合物材料（ MOFs）是一类具有特殊拓扑结构和可设计的孔道结构的新型多孔材料，加之其比表面积高、孔隙率大、热稳定性良好和溶剂耐受性好等特性，使得 MOFs 在分析化学领域的应用与研究日益深入。本文简要综述了手性 MOFs的合成方法，着重讨论了手性 MOFs在对映异构体选择性分离方面的应用及相关机理，最后对该类材料的发展前景做了展望。
Chirality is a universal phenomenon in nature. Chiral separation is vitally important in drug development,agricultural chemistry,pharmacology,environmental science,biology and many other fields. Chiral metal-organic frameworks( MOFs ) are a new group of porous materials with special topology and designable pore structures,as well as their high specific surface area,porosity,excellent thermal stability,solvent resistance,etc. Thus,chiral MOFs are promising with various applications in the field of analytical chemistry. This review summa-rizes the synthesis strategies of chiral MOFs and their applications in the selective separation of enantiomers,as well as related mechanism.
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