采用萃取纳升喷雾结合离子迁移谱技术，建立了化妆品中8种禁用抗生素的现场快速筛查方法。对萃取纳升喷雾毛细管拉制条件、萃取纳升喷雾离子化条件、离子迁移谱检测条件等进行了详细考察和优化。在优化的实验条件下，8种禁用抗生素的方法检出限为20 mg／kg，离子迁移谱分析时间小于20 ms，单个样品全部检测时间不超过30 s。对于筛检出的疑似阳性样品，进一步采用超高效液相色谱-串联质谱进行确证。该方法流程简便、快捷高效，为化妆品中违禁组分的现场快速筛查提供了较为广阔的应用前景。
A rapid on-site method has been developed for the identification of eight prohibited antibiotics in cosmetics using extraction nano-electrospray coupled with ion mobility spectrom-etry. The experimental conditions for capillary pulling,extraction nano-electrospray,and ion mobility spectrometry were investigated and optimized. Under the optimum conditions,the lim-its of detection( LODs)for the eight prohibited antibiotics were 20 mg/kg. The instrumental analysis time for a single ion mobility spectrometry run was less than 20 ms,and the total peri-od for sample analysis was less than 30 s. The suspicious positive samples were subjected to further verification by ultra-performance liquid chromatography-tandem mass spectrometry ( UPLC-MS/MS). The proposed method is rapid,efficient with greatly simplified work flows and can provide potential analytical possibility for outside-the-lab screening of cosmetics for the presence of illicit ingredients.
参考文献
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