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目的探讨腹腔镜下Roux-en-Y胃旁路术(LRYGB)在非病态肥胖患者2型糖尿病治疗中的应用价值。方法"以22例体重指数（BMI）介于25～35 kg/m²间的非病态肥胖2型糖尿病患者为研究对象，行LRYGB，观察手术前后BMI、空腹血糖和糖化血红蛋白的变化情况，分析与手术预后相关的因素。结果"22例患者均成功接受LRYGB，并完成术后12个月的随访。2例（9.1%）患者术后出现并发症，其中1例早期出现胃空肠吻合口出血，1例因发生腹泻需要重建肠绕道长度。术后第12个月，14例（63.6%）患者达到糖尿病治愈，6例（27.3%）血糖得到控制，2例（9.1%）血糖得到改善。与血糖控制或改善组患者相比，糖尿病治愈组患者手术前的BMI较高（P=0.001）、年龄较轻（P=0.002）、糖尿病病程较短（P=0.001）。结论"LRYGB可安全有效地治疗非病态肥胖2型糖尿病患者，此类患者早期行LRYGB干预可能效果更佳。

ObjectiveTo evaluate the effectiveness of laparoscopic Roux-en-Y gastric bypass (LRYGB) for achieving type 2 diabetes mellitus (T2DM) remission in patients with body mass index (BMI) in the range of 25-35 kg/m2. MethodsTwenty-two non-morbidly obese (BMI: 25-35 kg/m2) patients with T2DM underwent LRYGB. The changes of BMI, fasting plasma glucose (FPG), and glycosylated hemoglobin (HbA1c) levels were recorded, and the prognostic factors were analyzed. ResultsAll these 22 patients successfully underwent LRYGB and were followed up for twelve months. Two patients (9.1%) developed complications: one patient had an early hemorrhage at the gastrojejunostomy site, and the other had frequent loose stools that required revision surgery. At 12 months, 14 patients (63.6%) showed T2DM remission, 6 (27.3%) showed glycemic control, and 2(9.1%) showed improvement. Compared with the latter two groups, patients in the T2DM remission group had significantly higher BMI （P=0.001）, younger age （P=0.002）, and shorter duration of diabetes （P=0.001） before operation. ConclusionsLYRGB can efficiently and safely treat T2DM in non-morbidly obese patients. Early intervention in these patients may yield better outcomes."