综述了近10余年来稀土配合物药物研究进展以及发展趋势.研究现状反映出参与药物合成的稀土元素以镧、镨、钕和钐为主,配体以杂环化合物为多,药理作用研究主要集中在抗肿瘤、抗病毒以及抗菌等方面.在此基础上指出了稀土黄酮类配合物有望在抗骨质疏松症作用方面表现出良好的前景.
参考文献
| [1] | 吴集贵;邓汝温;曾正志 等.稀土在医药中的应用研究概况[J].有色金属与稀土应用,1994,6(01):19. |
| [2] | Hodnett M E;Mooney P D .Antitumor activities of some Schiff bases[J].Journal of Medicinal Chemistry,1970,13(04):786. |
| [3] | Hodnett M E;Dunn W J .Cobalt derivatives of schiff bases of aliphatic amines as antitumor agents[J].Journal of Medicinal Chemistry,1972,15(03):339. |
| [4] | Routier S.;Waring MJ.;Colson P.;Houssier C.;Bailly C.;Bernier JL. .SYNTHESIS OF A FUNCTIONALIZED SALEN COPPER COMPLEX AND ITS INTERACTION WITH DNA[J].The Journal of Organic Chemistry,1996(7):2326-2331. |
| [5] | Szkerke M .Cyclic phosphoramide mustard(NSC-69945)derivatives of amino acids and peptides[J].Cancer Treatment Reports,1976,60(04):347. |
| [6] | Cox P J .Cyclosphosphamide cystitis.Indentification of acrolein as the causative agent[J].Biochemical Pharmacology,1979,28(13):2045. |
| [7] | 孔德源,章雄文,朱勤.氨基酸类Schiff碱稀土配合物的合成及其抗肿瘤活性Ⅰ[J].中国药物化学杂志,1998(04):245-249,253. |
| [8] | 孔德源,谢毓元.氨基酸类Schiff碱稀土配合物的合成及抗肿瘤活性Ⅱ[J].中国药物化学杂志,1999(03):162. |
| [9] | 孔德源,卿晨,谢毓元.氨基酸类Schiff碱稀土配合物的合成及抗肿瘤活性Ⅲ[J].中国药物化学杂志,2000(01):13-17. |
| [10] | 李锦州,于文锦,李刚.噻吩甲酰基吡唑啉酮缩乙二胺稀土配合物的合成、表征及生物活性[J].应用化学,2000(03):280-283. |
| [11] | 李锦州,李刚,于文锦.呋喃甲酰基吡唑啉酮双席夫碱稀土配合物的合成、表征及生物活性[J].中国稀土学报,2000(01):71-74. |
| [12] | 李锦州,于文锦,蒋礼.酰基吡唑啉酮缩邻苯二胺希土配合物的合成、表征及生物活性[J].无机化学学报,2001(06):888-892. |
| [13] | 杨正银;王流芳;吴集贵 等.2-羰基丙酸(吡啶-4-甲酰基)腙稀土双核配合物的合成、表征及抗肿瘤活性[J].应用化学,1992,9(03):31. |
| [14] | 杨正银;王流芳;吴集贵.某些稀土希夫碱配合物的抗肿瘤活性药理研究[J].科学通报,1992(09):813. |
| [15] | 何水样,陈军利,杨锐,武望婷,赵建社,史启祯,王汝贤.水杨醛水杨酰腙及其稀土配合物的合成、波谱研究及生物活性[J].有机化学,2003(12):1387-1392. |
| [16] | 何水样,胡亭,杨锐,赵建社,薛岗林,史启祯.稀土与水杨醛-1H-苯并三唑乙酰腙配合物的合成及抑菌实验[J].应用化学,2003(03):205-209. |
| [17] | Xinping Yang;Penfei Xu;Qingxiang Gao .SYNTHESIS, CHARACTERIZATION, AND ANTITUMOR ACTIVITY OF SOME TRIVALENT LANTHANIDE COMPLEXES WITH 2-FORMYLPHENOXYACETIC ACID THIOSEMICARBAZONE[J].Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry,2002(1):59-68. |
| [18] | 曹凤歧.La、Pr、Nd、Sm--氧氟沙星配合物的合成、结构及抗菌活性[J].稀土,1993(05):37. |
| [19] | 杨波,王国清,齐秀兰,宋爱华,高宁星.La、 Ce、Nd-氧氟沙星配合物的制备及其抗菌活性[J].沈阳药科大学学报,2001(04):268-270. |
| [20] | 王国平,雷群芳.钆（Ⅲ）-喹诺酮配合物的合成、抗菌活性与抗肿瘤活性[J].浙江大学学报(理学版),2003(04):417-421. |
| [21] | 杨一心,赵天成,张泉珍,贾敬肖,薛岗林,宋迪生.稀土氯化物与咪唑配合物的合成、表征及抑菌作用[J].西北农业大学学报,1998(01):94-98. |
| [22] | 赵天成;杨一心;黄岳云 等.氯化物稀土与苯并咪唑配合物的合成及生物活性[J].西北农业大学学报(自然科学版),1999,29(06):543. |
| [23] | 何水样;胡亭;李焕勇.RE(Ala)3Im(ClO4)3@H2O的合成及对棉花黄萎病菌的作用[J].化学通报,1999:34. |
| [24] | 何水样,陈军利,张维平,刘向荣,宋迪生.RE（ClO4）3*nH2O与丙氨酸、 咪唑配合物的合成、表征及生物活性[J].中国稀土学报,2001(01):80-84. |
| [25] | Monafo W W;Tandon S N;Ayazian V H et al.Cerium nitrate:a new topical antiseptic for etensive burns[J].Surgery,1976,80:465. |
| [26] | Fox C L;Monafo W W;Ayazian V H .Comparative efficacy of typo-,iso-,and hypertonic sodium solutions in experimental burn shook[J].Surgery Gynecology and Obstetrics,1977,144:686. |
| [27] | 吴集贵,邓汝温.磺胺嘧啶稀土络合物的研究[J].中国稀土学报,1985(02):7. |
| [28] | 1-（2'-硫代乙酸）-3-甲基-4-丁基-5-羟基嘧啶及其稀土配合物的合成和其抗菌活性[J].兰州大学学报,1993(02):99. |
| [29] | 张仲生;吴集贵;邓汝温 等.邻菲口罗啉与四氧嘧啶稀土化合物的合成及抑菌作用[J].兰州大学学报(自然科学版),1990,26(04):69. |
| [30] | 林纪筠;马德建;钟文元 .稀土-邻菲口罗啉-氟尿嘧啶三元配合物的合成及表征[J].中国稀土学报,1996,14(03):193. |
| [31] | Yongping Zhang;Ning Tang .SYNTHESIS, CHARACTERIZATION AND ANTITUMOR ACTIVITY OF COMPLEXES OF LANTHANIDE NITRATES WITH BIS(2-PYRIDYL-N-OXIDE) DISULFIDE[J].Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry,2000(10):1995-2008. |
| [32] | 张永平,范丽岩,唐宁,谭民裕.三苦味酸根·2，2＇-二硫代二（N-氧化吡啶）合稀土（Ⅲ） 配合物的合成、表征及其抗肿瘤活性研究[J].无机化学学报,2001(03):427-430. |
| [33] | Hill C L;Weeks M S;Schinazi R F .Anti-HIV activity,toxicity and stability studies of representative strucural families of polyoxometalates[J].Journal of Medicinal Chemistry,1990,33:2767. |
| [34] | Hill C L;Kim G S;Prosser-Mccartha C M et al.Polyoxometalates in catalytic selective homogeneous oxygenation and anti-HIV chemotherapy[J].Mol Engineering,1993,3:263. |
| [35] | Yamase I;Tokutake Y;Yoshida T et al.Antiviral activity of polyoxomolybooeuropate PM-104 against human immunodeficiency virus type I[J].Chemical and Pharmaceutical Bulletin,1991,39:1638. |
| [36] | 刘术侠;刘彦勇;王恩波 .13-钒镍(锰)杂多酸稀土盐的合成及其镨盐抗肿瘤活性的研究I[J].化学学报,1996,54:673. |
| [37] | 刘杰,王恩波,周云山,胡长文.稀土杂多配合物的合成及抗流感病毒的活性研究[J].药学学报,1998(07):544-547. |
| [38] | 刘杰,王恩波,周云山,彭筠.稀土杂多配合物的抗流感病毒活性[J].中国稀土学报,1998(03):257-261. |
| [39] | 刘术侠.Keggin结构钨磷酸稀土镨盐杂多蓝的合成及抗艾滋病病毒（HIV-1）活性的研究[J].高等学校化学学报,1996(08):1188. |
| [40] | 刘杰,梅文杰,李安兴,谭彩萍,石硕,计亮年.混合价态钨硼稀土杂多蓝在MDCK细胞内抑制流感病毒的活性[J].高等学校化学学报,2004(01):1-6. |
| [41] | 刘杰,王恩波,彭军,胡长文,阎淑珍.铌取代型钨硅杂多酸盐的合成及抗病毒活性研究[J].高等学校化学学报,1998(07):1029-1031. |
| [42] | 刘杰.稀土钼磷杂多蓝的合成、性质及防治植物病毒的研究[J].中国稀土学报,1999(01):65. |
| [43] | HONG ZHANG;YANG LAN;LI-YING DUAN .SYNTHESIS, PROPERTIES AND CRYSTAL STRUCTURE OF A NEW 12-MOLYBDOGERMANIC SALT OF LANTHANUM COORDINATED TO N-METHYL-2-PYRROLIDONE[J].Journal of Coordination Chemistry,2003(2):85-94. |
| [44] | Vincke E;Sucker E .Nd salt of 3-salfoisonicotimic acid as an antithrombotic[J].Klin Wschr,1950,28:74. |
| [45] | Deng R W;Wu J G;Long L S .Lanthanide complexes of ethyl biscoumocetate and their anticoagulant action[J].Synthesis and Reactivity in Inorganic and Metal-organic Chemistry,1993,23(04):493. |
| [46] | Deng R W;Wu J G;Long L S .Lanthanide complexes of di(4-hedroxycoumarinyl-3) acetic acid and their anticoagulant action[J].Bulletin des Societes Chimiques Belges,1992,101(05):439. |
| [47] | Sperling R .Metal binding properties of γ-carboxyglutamic acid[J].Journal of Biological Chemistry,1978,253:3898. |
| [48] | Nath B B .Dissociation and ciation of some coumarins and in mdanedioues[J].Indian Journal of Biochemistry and Biophysics,1982,19(01):32. |
| [49] | Cacheris W P;Nickle S K;Sherry A D .Dissociation kinetic of cerium(Ⅲ) complexes of macrocyclic polyaza polycarboxylate ligands TETA and DOTA[J].Inorganic Chemistry,1987,26:958. |
| [50] | 陈德福.稀土氮杂大环多羧酸配合物Na[Ln（DOTMA）（H2O）]·2H2O的合成与表征[J].高等学校化学学报,1996(08):1179. |
| [51] | Liu Y M;Wang Z P;Zhang Z H et al.Synthesis,characterization and antitumor activity of ternary complexes of all-trans retinoic acid with rare earth metals[J].Journal of Coordination Chemistry,1999,47(03):441. |
| [52] | 李勤喜,宋玉民,王流芳,王印月.Y（RA）3·4H2O的合成及其抗白血病HL-60细胞的研究[J].兰州大学学报（自然科学版）,2004(01):45-49. |
| [53] | Lin Yang;Dongliang Tao;Xiaoli Yang;Yongfang Li;Yuming Guo .Synthesis, Characterization, and Antibacterial Activities of Some Rare Earth Metal Complexes of Pipemidic Acid[J].Chemical and Pharmaceutical Bulletin,2003(5):494-498. |
| [54] | Karthikeyan G;Mohanraj K;Elango K P .Synthesis,spectroscopic characterization and antibacterial activity of lanthanide-tetracycline complexes[J].Transactions Metal Chemistry,2004,29:86. |
| [55] | Zhou J;Wang LF;Wang JY;Tang N .Synthesis, characterization, antioxidative and antitumor activities ofsolid quercetin rare earth(III) complexes[J].Journal of Inorganic Biochemistry: An Interdisciplinary Journal,2001(1):41-48. |
| [56] | 高锦章,龙全江,杨韬.中国稀土药物研究进展[J].西北师范大学学报(自然科学版),2002(01):108-111. |
| [57] | 张金超 .外源性金属离子对破骨细胞、破骨细胞样细胞和成骨细胞的影响[D].北京大学,2003. |
| [58] | 张金超,许善锦,王夔,于世凤.稀土离子对体外兔成熟破骨细胞骨吸收功能的影响[J].科学通报,2003(16):1767-1771. |
| [59] | Zhang Jinchao;Zhang Tianlan;Xu Shanjin.Effects of lanthanum(Ⅲ) on bone resorbing activity of rabbit mature osteoclasts co-cultured with osteoblasts[J].Journal of Rare Earths |
| [60] | Zhang Jinchao;Zhang Tianlan;Xu Shanjin .Effects of Lanthanum on Formation and Bone-Resorbing Activity of Osteoclast-Like Cells[J].Journal of Rare Earths,2004(6):891-895. |
| [61] | 张金超,李晓新,许善锦,王夔,于世凤,林琴.稀土离子对体外培养的成骨细胞增殖、分化和功能表达的影响[J].自然科学进展,2004(04):404-409. |
| [62] | Wattel A;Kamel S;Mentaverri R;Lorget F;Prouillet C;Petit JP;Fardelonne P;Brazier M .Potent inhibitory effect of naturally occurring flavonoids quercetin and kaempferol on in vitro osteoclastic bone resorption.[J].Biochemical Pharmacology,2003(1):35-42. |
| [63] | Wattel A;Kamel S;Prouillet C;Petit JP;Lorget F;Offord E;Brazier M .Flavonoid quercetin decreases osteoclastic differentiation induced by RANKL via a mechanism involving NF kappa B and AP-1.[J].Journal of Cellular Biochemistry,2004(2):285-295. |
| [64] | Prouillet C;Maziere JC;Maziere C;Wattel A;Brazier M;Kamel S .Stimulatory effect of naturally occurring flavonols quercetin and kaempferol on alkaline phosphatase activity in MG-63 human osteoblasts through ERK and estrogen receptor pathway.[J].Biochemical Pharmacology,2004(7):1307-1313. |
| [65] | Notoya M;Tsukamoto Y;Nishimura H;Woo JT;Nagai K;Lee IS;Hagiwara H .Quercetin, a flavonoid, inhibits the proliferation, differentiation, and mineralization of osteoblasts in vitro.[J].European Journal of Pharmacology: An International Journal,2004(1/3):89-96. |
| [66] | 蔡曼玲;季晖;刘悦 等.五种淫羊藿黄酮类成分对体外培养成骨细胞的影响[J].中国药理通讯,2004,21(03):13. |
| [67] | Yamaguchi M;Sugimoto E .Stimulatory effect of genistein and daidzein on protein synthesis in osteoblastic MC3T3-E1 cells:activation of aminoacyl-tRNA synthetase[J].Molecular and Cellular Biochemistry,2000,214(1-2):97. |
| [68] | Yamaguchi M .Isoflavone and bone metabolism:its cellular mechanism and preventive role in bone loss[J].Journal of Health Science,2002,48(03):209. |
| [69] | Gao YH;Yamaguchi M .Suppressive effect of genistein on rat bone osteoclasts: apoptosis is induced through Ca2+ signaling.[J].Biological & pharmaceutical bulletin,1999(8):805-809. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%