以不同分子量的壳聚糖为原料制备了一系列羧甲基壳聚糖，测定了取代度（DS）和分子量(Mη)，并用FT-IR及13CNMR进行了分子结构表征.结果表明,在2位氨基及3、6位羟基上均发生了羧甲基化反应，产物为N,O-羧甲基壳聚糖(NOCC).取代度大小顺序为:OH-6＞OH-3＞—NH2,且总取代度随壳聚糖分子量的降低明显增大.N,O-羧甲基壳聚糖具有与透明质酸相似的吸湿、保湿效果，其吸湿性能随分子量的增大而增强，保湿性能随取代度的增高而增强，分子量介于0.56×104～8.6×104，取代度大于1.0的产品，其保湿性能优于透明质酸.
A series of N,O-carboxymethylchitosan(CM-chitosan) were prepared.The position and degree of substitution were determined by potentiometric titration, IR and 13C NMR. The results indicated that the degree of substitution of the compounds increased significantly with decrease of molecular weight of chitosan and the carboxymethylation reactivity decreased in the order OH-6＞OH-3＞NH2. The moisture-absorption and moisture-retention properties of CM-chitosans and moisture-retention properties of CM-chitosans were found quite similar to those of hyaluronic acid. The moisture absorbability increased with increasing in molecular weight and moisture retention capacity of CM-chitosas with the degree of substitution. The CM-chitosans with molecular weight from 0.56×104 to 8.6×104 and degree of substitution greater than 1.0 had better moisture-absorption moisture-retention capacity than hyaluronic acid.
参考文献
| [1] | Muzzarelli R A A. Carbohydr Polym,1988,(8):1 |
| [2] | Shuichi Matsumura,Han Ching Cheng,Masahiro Minami, et al. Oil Chem,1989,38:492 |
| [3] | Xu J,Stephen P M,Richard A G. Macromolecules,1996,29:3436 |
| [4] | Wang W,Bo S Q,Qin W. Acta Polymerica Sinica,1992,2:202 |
| [5] | Nishimura N S,Nishi N,Tlkure S. Carbohydr Res,1986,146:251 |
| [6] | Muzzarelli R A A. Carbohydr Res,1982,107:199 |
| [7] | XU Chen（许晨），LU Can-Hui（卢灿辉）. Yingyong Huaxue(应用化学),1996,13(5):94 |
- 下载量()
- 访问量()
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%