采用自由基溶液聚合方法制备甲基丙烯酸(MAA)和poloxamer的共聚物水凝胶，研究药物在此水凝胶中的扩散行为.由于MAA与poloxamer中乙氧基(EO)的氢键络合作用，水凝胶的溶胀和水凝胶中药物的扩散具有pH敏感性，络合状态水凝胶(pH为4.0)中氢溴酸右美沙芬和维生素B12的扩散系数在10-11～10-8 cm2／s之间，溶胀状态时(pH为7.0)为10-7～10-6cm2／s.EO与MAA的摩尔比是影响水凝胶平衡溶胀和药物在水凝胶中的分配与扩散性质的重要因素.
The pH-sensitive hydrogel networks comprising of MAA and poloxamer were synthesizedby free-radical solution polymerization. The gels exhibit pH-dependant solute diffusivity due to theformation or disruption of hydrogen bondings between MAA and EO unit in poloxamer molecules.The values of diffusion coefficients of dextromethorphan (DMP) and vitamin (Vb12) were found inrange from 10-7 to 10-6 cm2/s in uncomplexed hydrogels (pH 7.0) and from 10-11 to 10-8 cm2/s incomplexed hydrogels(pH 4.0) ,respectively. Solute diffusivity decreased as solute size increased. Themole ratio of EO unit to MAA unit is the main factor that affects equilibrium swelling, solute partitionand permeability characteristics of these hydrogels.
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