研究了DCC偶联法由腈代乙酸与取代胺合成腈代乙酰胺的新方法.在等摩尔的腈代乙酸、取代胺的溶液中,滴加等摩尔的DCC.然后加热回流反应,TLC跟踪.粗品用适当的溶剂重结晶或层析得到产品腈代乙酰胺,产品用mp、IR和NMR测试技术表征.结果表明,伯胺、仲胺、芳胺等均可用本法简便地制得相应的腈代乙酰胺,收率52%～90%,纯度≥95%.
参考文献
| [1] | Okujima H,Narimatsu A,Shimooda R.JP 58 148 865[P],1984 |
| [2] | Kampe K D,Estel H,Henbachn G.CH 630 342[P],1982 |
| [3] | Walker G N.US 4 435 407[P],1984 |
| [4] | Resch J F.DD 249 011[P],1988 |
| [5] | Seele T,Koehler V.DD 221 738[P],1986 |
| [6] | Phyllis D,Stephen R,Olwa O.J Chem Soc Perkin Trans I[J],1977,2:93 |
| [7] | Quac B,Seeger H,Juergen D.DE 2 538 254[P],1977 |
| [8] | SHAO Jian-Guo(绍建国),WANG Pei-Yu(王佩玉),ZHENG Ming(郑鸣),Zhong Qi(钟琦).J Yangzhou Univ(扬州大学学报)[J],1998,51(2):17 |
| [9] | Ailsa L,Roger L,John L,Phillips J N.Aust J Chem[J],1976,29:1 039 |
| [10] | Baburao M,Subhash P,Edward R.Synth Commun[J],1990,20(20):3 235 |
| [11] | Shriner R L,Fuson R C,Curtin D Y,Morrill T C.The Systematic Identication of Organtic Compounds[M],6th Ed.New York:John Wiley & Sons.1980:271 |
| [12] | Sadtler Research Laboratories.Inc.SADTLER Standard Infrared Grating Spectra[M].Philadelphia:Researchers,Editors and Publishers,(a)45799P;(b)50056K;(C)50057k,1976 |
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