以β-紫罗兰酮为起始原料,用间氯过氧苯甲酸代替铬氧化剂氧化环氧化、开环、乙酰丙酮钴催化氧气烯丙位氧化、Wittig反应、碱性水解5步反应,以39%的总收率合成了植物激素3-甲基-5-(1-羟基-4-氧代-2,6,6-三甲基-2-环己烯基)-2,4-戊二烯酸(脱落酸),用IR、~1H NMR、MS及元素分析等测试技术表征了产物的结构.
With β-ionone as the starting material, the plant hormon abscisic acid, 3-methyl-5-(1-hydroxy-4-oxo-2,6,6-trimethyl-2-cyclohexene-1-yl)-2,4-pentadienoicacid, was synthesized via epoxidation by oxidant metachloroperbenzoic acid instead of chromium oxidant, ring-opening, allylic oxidation with oxygen catalyzed by Co(acac)_2, Wittig rection and basic hydrolysis in a total yield of 39%. The structures were characterized by IR, ~1H NMR, MS and elemental analysis.
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