应用等组分晶体生长方法,研究了牙本质晶、羟基磷灰石、釉质晶脱矿动力学.并探索了磷蛋白对牙本质晶脱矿动力学过程的影响.实验条件为:溶液温度:T=37±0.5℃;溶液酸度:pH=4.5±0.03;初始离子强度:IS=0.15mol/L;溶液的饱和度:δ＝-0.60;-0.74;-0.86.研究结果表明:当δ=-0.60时,牙本质晶、釉质晶和羟磷灰石脱矿反应过程的特征明显不同.前两者的饱和溶解量比后者大一个数量级.羟磷灰石的特征反应周期比釉质晶和牙本质晶短15倍左右,初始反应速率慢30倍.牙本质晶脱矿初始反应速率Ri随δ的减低而快速增加.磷蛋白对牙本质晶的脱矿过程起抑制作用,但存在临界值.当磷蛋白在溶液中的浓度超过临界值后,其反应速率的变化很小.磷蛋白抑制作用在较大程度上依赖于溶液的饱和度.
参考文献
| [1] | BUTLER W T;Munksgaard E C et al.Dentin Proteins:Chemistry,Structure and Biosynthesis[J].Journal of Dental Research,1979,58:817-824. |
| [2] | Boskey A L;Maresca Michael;Steven Doty et al.Concentration-dependent Effects of Dentin Phosphophoryn in the Regulation of in Vitro Hydroxyapatite Formation and Growth[J].Bone and Mineral,1990,11:55. |
| [3] | BUTLER W T .Dentin Matrix Proteins and Dentinogenesis[J].Connective Tissue Research,1995,33(1-3):59-65. |
| [4] | CHANG S R;Holland G R;Clarkson B H .Effects of Phosphophoryn on Collagen Fibril Calcium Deposition[J].Journal of Dental Research,1998,77:176. |
| [5] | Clarkson B H;Chang S R;Holland G R .Phosphoprotein Analysis of Sequential Extracts of Human Dentin and the Determination of the Subsequent Remineralization Potential of These Dentin Matrices[J].Caries Research,1998,32:357. |
| [6] | Dahl T.;Sabsay B.;Veis A. .Type I collagen-phosphophoryn interactions: Specificity of themonomer-monomer binding[J].Journal of Structural Biology,1998(2):162-168. |
| [7] | 陈万春.等组分（浓度）溶液晶体生长方法及其应用[J].物理,1988(10):598. |
| [8] | 张克从;张乐;NFDB2.晶体生长科学和技术[M].北京:科学出版社,1997 |
| [9] | Chen W C;Kolopajlo L;Salimi M H;Nancollas G H .The Deminera-lization and Remineralization of Tooth Enamel,A Constant Composition Kinetics Study[J].Journal of Dental Research,1984,63:202. |
| [10] | Chen W C;Nancollas G H .The Kinetics of Dissolution of Tooth Enamel,A Constant Composition Study[J].Journal of Dental Research,1986,65:663. |
| [11] | White D J;Chen W C;Nancollas G H .Kinetic and Physical Aspects of Enamel Remineralization-A Constant Composition Study[J].Caries Research,1988,22:11-19. |
| [12] | 陈万春 .HAP和牙釉晶溶解动力学的等组分方法研究[J].硅酸盐学报,1988,16(06):523. |
| [13] | 陈万春.晶体溶解动力学实验方法研究[J].人工晶体学报,1991(02):107. |
| [14] | Chen W C;Liu D D;LU P D .A Study on Induction Time for Nucleation of Calcium Phosphate Crystals[J].科学通报(英文版),1991,36(23):1962. |
| [15] | Gao X J;Chen W C .Constant Composition on Enamel Dissolution in Calcium Phosphate System[J].Journal of Dental Research,1994,73:418. |
| [16] | 高学军;刘志萍;刘道丹;陈万春 .牙釉质脱矿动力学研究[J].中华口腔医学杂志,1996,31(01):51. |
| [17] | Gao X J;Elliott J C;Anderson P .Scanning and Constact Microradiograophic Study of the Effect of Degree of Saturation on the Rate of Enamel Mineralization[J].Journal of Dental Research,1991,70:1332. |
| [18] | Margolis HC;Zhang YP;Lee CY;Kent RL Jr;Moreno EC .Kinetics of enamel demineralization in vitro.[J].Journal of Dental Research: Official Publication of the International Association for Dental Research,1999(7):1326-1335. |
| [19] | Paschalis E P;Tan J;Nancollas G H .Constant Composition Dissolution Kinetics Studies of Human Dentin[J].Journal of Dental Research,1996,75(04):1019. |
| [20] | Graeme K;Hunter;Peter V;Hauschica,ARobin Poole et al.Nucleation and Inhibition of Hydroxyapatite Formation by Mineralized Tissue Proteins[J].Journal of Biochemistry,1996,317:59. |
| [21] | Gu K;Chang S R;Slaven M S et al.Human Dentin Phosphophoryn Nucleotide and Amino Acid Sequence[J].European Journal of Oral Sciences,1998,106(06):1043-47. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%