采用扫描电子显微镜(SEM)和X射线衍射(XRD)方法,比较研究了防石药物柠檬酸钾(K3cit)在尿石患者尿液和正常人尿液制备的凝胶中对草酸钙(CaOxa)晶体生长的影响.没有加入K3cit时,CaOxa晶体均以一水草酸钙(COM)为主要晶相,加入K3cit后,不但COM晶体变得圆钝,比表面积减小,而且诱导了二水草酸钙(COD)生成.随着K3cit浓度从0.10增加到0.20 mol/L,在正常人尿液凝胶中COD晶体的百分含量从20%增加到45%,而在CaOxa结石患者尿液凝胶中,不但COD含量从10%增加到25%,而且K3cit可诱导草酸钙成核,从而产生大量的小尺寸草酸钙晶体,这有利于阻止草酸钙晶体变大形成尿石.本结果可为临床上治疗CaOxa结石提供启示.
参考文献
| [1] | Pak CY;Heller HJ;Pearle MS;Odvina CV;Poindexter JR;Peterson RD .Prevention of stone formation and bone loss in absorptive hypercalciuria by combined dietary and pharmacological interventions.[J].The Journal of Urology,2003(2):465-469. |
| [2] | 曹正国,刘继红,胡少群,吴继洲,尹春萍,叶章群.中药泽泻不同部位提取物对草酸钙结晶形成影响的体外实验研究[J].临床泌尿外科杂志,2003(01):40-42. |
| [3] | Chow K;Dixon J;Gilpin S;Kavanagh JP;Rao PN .Citrate inhibits growth of residual fragments in an in vitro model of calcium oxalate renal stones.[J].Kidney International,2004(5):1724-1730. |
| [4] | Ouyang JM .Identification of urinary stone components by X-ray photoelectron spectroscopy[J].Spectroscopy Letters,2004(6):633-641. |
| [5] | Tarkan S;Aysegul A;Sadettin K .Effect of Potassium Citrate Therapy on Stone Recurrence and Residual Fragments After Shockwave Lithotripsy in Lower Calcium Oxalate Urolithiasis[J].Journal of Endocrinology,2002,16(03):149-152. |
| [6] | 口服枸橼酸钾镁预防复发性草酸钙结石的效果[J].中华泌尿外科杂志,1998(06) |
| [7] | 陈村元,郑辉,欧阳健明.凝胶体系中生物矿物生长的研究进展[J].人工晶体学报,2005(05):926-930. |
| [8] | 杨德同;管智坚;庄起涛 .草酸钙在凝胶中的周期沉淀和化学不稳定性--尿结石鲕状结构探讨[J].化学物理学报,1995,8(04):380-383. |
| [9] | 郑辉,李祥平,欧阳健明.过饱和度、反应物化学计量比及离子强度对草酸钙晶体生长的影响[J].无机化学学报,2005(09):1375-1378. |
| [10] | Ouyang Jianming,DENG Suiping,LI Xiangping,TAN Yanhua,Bernd Tieke.Effects of temperature and sodium carboxylate additives on mineralization of calcium oxalate in silica gel systems[J].中国科学B辑(英文版),2004(04):311-319. |
| [11] | Khan S R;Whalen P O;Glenton P A .Heterogeneous Nucleation of Calcium Oxalate Crystals in the Presence of Membrane Vesicles[J].Journal of Crystal Growth,1993,134:211-218. |
| [12] | Nayir A .Determination of urinary calculi by binocular stereoscopic microscopy.[J].Pediatric nephrology: journal of the International Pediatric Nephrology Association,2002(6):425-432. |
| [13] | 邓耀良;覃光熙 .草酸钙结石患者尿液中柠檬酸/草酸比值[J].中华实验外科杂志,1994,11(04):205-206. |
| [14] | Yara M .Urinary Excretion of Glycosaminoglycans in Normal and Stone Forming Subjects[J].Kidney International,1989,36:1022-1028. |
| [15] | Deng SP;Ouyang JM .Effects of dipalmitoylphosphatidylcholine monolayers to the crystallization of calcium oxalate monohydrate from the solution containing chondroitin sulfate C[J].Colloids and Surfaces, A. Physicochemical and Engineering Aspects,2005(0):47-50. |
| [16] | King M;McClure W F;Andrews L C;Holomery M A.Powder Diffraction File Alphabetic Index,Inorganic Phases/Organic Phases.1601 Park Lane Pennsylvania[M].U.S.A:International Center For Diffraction Data,1992:19081-12389. |
| [17] | Donnet M.;Lemaitre J.;Bowen P.;Jongen N. .New morphology of calcium oxalate trihydrate precipitated in a segmented flow tubular reactor[J].Journal of Materials Science Letters,2000(9):749-750. |
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