介绍了纳米粒子探针的概念、检测原理及分类.评述了纳米粒子探针在DNA检测、蛋白质检测及药物靶向运输中的应用,总结了纳米粒子探针在放大检测信号、避免蛋白质变质和有效降低负面效应等方面的优缺点,并对将来纳米粒子探针在有效靶向释药和多功能分析等方面的发展进行了展望.
参考文献
| [1] | LIN Y S;TSAI P J;WENG M F et al.Affinity capture using vancomycin-bound magnetic nanparticles for the MALDI-MD analysis of bacteria[J].Analytical Chemistry,2005,77:1753-1760. |
| [2] | 潘沁,许利剑,王志飞,陆祖宏,何农跃.纳米金标记电化学检测DNA特异性结合蛋白[J].高等学校化学学报,2007(12):2290-2294. |
| [3] | 孙伟,尤加宇,江宏,焦奎.纳米粒子标记DNA探针的制备与检测应用[J].中国卫生检验杂志,2005(08):1008-1010. |
| [4] | 吴维明,蔡强,陈裕泉.纳米金在生物检测中的应用[J].国外医学(生物医学工程分册),2003(05):193-197. |
| [5] | 沈星灿,何锡文,梁宏.纳米粒子特性与生物分析[J].分析化学,2003(07):880-885. |
| [6] | LING X;XIN F H;JIAN M Z et al.Reduced photo-instability of luminescence spectrum of core-shell CdSe/CdS nanoerystals[J].Journal of Materials Science,2000,35:1375-1378. |
| [7] | 张乃青,崔一平,张家雨.不同壳层的CdS/ZnS核/壳结构量子点的温度相关荧光性质[J].纳米科技,2009(02):51-56. |
| [8] | M. Michihata;Y. Takaya;T. Hayashi .Development of the nano-probe system based on the laser-trapping technique[J].CIRP Annals,2008(1):493-496. |
| [9] | MUSICK M D;HE L;NICEWANRNER S R et al.Colloidal Au-enhanced surface plasma resonance for ultrasensitive detection of DNA hybridization[J].American Chemical Society,2000,122(38):9071-9077. |
| [10] | 刘四运,徐晟,彭卿.稀土掺杂SiO2与SiO2@Au纳米球[J].无机化学学报,2007(09):1657-1661. |
| [11] | 赵强,庞小峰.磁性纳米生物材料研究进展及其应用[J].原子与分子物理学报,2005(02):222-225. |
| [12] | 毕如意,钟国伦,孙建中.功能化高分子磁性微球制备技术研究进展[J].科技通报,2008(02):246-251. |
| [13] | 孟繁宗,王东来,翟玉春.荧光磁性双功能Fe3O4@PHEMA-Tb微球的制备及其蛋白固定化[J].过程工程学报,2009(01):101-106. |
| [14] | MIRKIN C A;LETSINGER R L;MUCIC R C et al.A DNA-based method for rationally assembling nanoparticles into macroscopic materials[J].Nature,1996,382:607-609. |
| [15] | TATON T A;MIRKIN C A;LETSINGER R L .Scanometric DNA array detection with nanoparticle probes[J].Science,2000,289(08):1757-1760. |
| [16] | TAYLOR J R.Use of microhotplates in the controlled growth and characterization of metal oxides for chemical sensing[J].Journal of Electroceramics,2002(09):122-147. |
| [17] | 王楠,徐淑坤,王文星.纳米金生物探针及其应用[J].化学进展,2007(02):408-413. |
| [18] | CAI H;XU Y;ZHU Z Z et al.An electrochemical DNA hybridizationdetection based on a silivernanoparticle label[J].Analyst,2002,127(06):803-808. |
| [19] | 罗贵华,徐怀德,高志贤,胡志华,周焕英,刘楠.纳米金标记DNA的生物传感器[J].解放军预防医学杂志,2007(02):91-93. |
| [20] | FAULK W P;TAYLAR G M.Cultivation of microvascular endothelial cells from human perputial skin[J].Immunocytochemistry,1971(08):1080-1084. |
| [21] | NAM J M;JINSOO K;JAE W L et al.Nanostructured titania membranes with improved thermal stability[J].Science,2003,301:1884-1886. |
| [22] | 贺明星,李凯,周宇荀,肖君华.纳米生物条形码技术在分子诊断中的应用[J].生命的化学,2008(01):86-88. |
| [23] | 郝兰群,郭胜清,郭振泉,宋凤卿,刘云.抗蓖麻毒素单克隆抗体的制备及应用[J].细胞与分子免疫学杂志,2003(05):517-518. |
| [24] | 钟晓琴,刘美英,黄云艳,贾春平,金庆辉,赵建龙,李凤民.一种基于酶标纳米金探针的蛋白质检测方法[J].中国医药生物技术,2009(03):200-206. |
| [25] | HUSSAIN M A;AGNIHOTRI A;SIEDLECKI C A .Evaluation of immunogenicity and reactogenicity of recombinant DNA hepatitis B vaccine produced in India[J].Langmuir,2005,21:6979-6986. |
| [26] | ZHANG J L;MISRA R D K.Synthesis and bioactivity of six-ring nucleoside modified siRNA[J].Acta Biomaterialia,2007(03):838-850. |
| [27] | 刘聪颖,胡建华,杨东,杨武利.多重响应性介孔二氧化硅纳米微球的制备及载药研究[J].化学学报,2009(08):843-849. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%